hormone-sensitive lipase (hsl)

HSL-IN-3 (HSL inhibitor 3) is a boronic acid derivative that is an inhibitor of hormone-sensitive lipase(HSL).

Hi 76-0079 (NNC0076-0079) is a hormone-sensitive lipase (HSL) inhibitor with an IC50 of 184 nM.Hi 76-0079 is a potential compound for the study and prevention of obesity and diabetes.

HSL-IN-1 is an orally active and highly potent hormone-sensitive lipase (HSL) inhibitor that significantly reduces the reactive metabolite load and can reduce the release of free fatty acids from stored fat.

HSL-IN-2 is a selective inhibitor of Hormone Sensitive Lipase (HSL; IC50: 0.023 μM).

HSL-IN-5 (Example 21) is a hormone-sensitive lipase (HSL) inhibitor with an IC₅₀ value of 0.2 μM, suitable for diabetes research.

Lys-γ3-MSH(human) TFA, a melanocortin peptide originating from the C-terminal fragment of pro-opiomelanocortin (POMC), enhances the steroidogenic response of rat adrenal glands to adrenocorticotrophin (ACTH). It is a potent stimulator of lipolysis, demonstrating an apparent EC50 of 3.56 nM, by activating hormone-sensitive lipase (HSL) and Perilipin A, leading to lipolysis [1] [2].