hiv-1 nef

HIV-1 Nef-IN-1 is an inhibitor of the HIV-1 Nef protein, effectively competing for Nef-SH3Hck interactions (Kd: 6.7 μM).

HIV-IN-6 is an HIV viral inhibitor that inhibits the replication of the HIV virus.HIV-IN-6 has anti-HIV viral activity and works by targeting Src family kinases (SFK) (e.g., Hck) that interact with the viral Nef protein.

Hck-IN-1 is a selective Nef-dependent Hck inhibitor (IC50s: 2.8 μM and >20 μM for Nef:Hck complex and Hck) with antiretroviral activity. Hck-IN-1 is a direct and wide HIV-1 Nef antagonist with an IC50 of 100-300 nM for wild-type HIV-1 replication.

DQBS is an HIV-1 Nef function antagonist.

DLC27-14 is an HIV-1 Nef specific protein disorder catalyzer.

Tat-beclin 1scrambled is the disordered segment and control of Tat-beclin 1, derived from a region of the autophagy protein beclin 1. Beclin 1 induces autophagy by interacting with HIV-1Nef and the autophagy inhibitory factor GAPR-1 (GLIPR2). Tat-beclin 1 decreases both the accumulation of polyglutamine-expanded protein aggregates and the replication of several pathogens, such as HIV. Additionally, Tat-beclin 1 reduces mortality rates in mice infected with chikungunya or West Nile virus.