histamine phosphate

Histamine phosphate is a potent agonist of histamine receptors and a vasodilatory neurotransmitter. It can activate nitric oxide synthase and is commonly used to induce gastric ulcer models.

trans-Ned 19 is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist and two-pore channel (TPC) blocker. It binds with high affinity to the NAADP receptor to inhibit NAADP-dependent lysosomal/endolysosomal calcium release without affecting IP3 or cADPR-mediated calcium signaling pathways. Functionally, trans-Ned 19 inhibits glucose-induced calcium oscillations in pancreatic islets and low histamine concentration-induced endothelium-dependent vasodilation, and reduces Ebola virus infection of host cells. In immunomodulation, NAADP signaling blockade by trans-Ned 19 promotes the conversion of mouse Th17 cells to regulatory T cells (Tregs) and shows protective effects in intestinal inflammation models.

Antazoline phosphate is an antihistamine with anticholinergic properties. Antazoline prevents the typical allergic symptoms on capillaries, mucous membranes, skin, and gastrointestinal and bronchial smooth muscles by antagonizing the histamine H1 receptor