gp41

Trilobatin (P-Phlorizin) has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially inhibits the lipopolysaccharide (LPS)-induced inflammatory response by suppressing the NF-κB signaling pathway.Trilobatin shows a strong inhibitory activity against α-glucosidase and a moderate inhibitory activity against α-amylase for management of postprandial hyperglycemia with less side effect.

Theaflavin 3,3'-digallate, a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it reduces tumor angiogenesis by downregulating HIF-1αand VEGF.

HIV-1 env Protein gp41 (1-23) amide (isolates BRU/JRCSF) is a polypeptide molecule with the sequence AVGIGALFLGFLGAAGSTMGARS-NH2.

HIV (gp41) Fragment AVGIGA is a polypeptide molecule with the sequence AVGIGA.

Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-Fgr, phosphorylase kinase and TAOK2. Staurosporine also induces apoptosis.

PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelial growth factor receptor 2 (VEGFR2), c-kit, platelet-derived growth factor receptor (PDGFR) and FMS-like tyrosine kinase 3 (FLT3) tyrosine kinases, which may result in disruption of the cell cycle, inhibition of proliferation, apoptosis, and inhibition of angiogenesis in susceptible tumors.

5M038, a novel inhibitor of HIV envelope-mediated fusion, strongly inhibits gp41-mediated membrane fusion.

NB-64 is a HIV-1 entry inhibitor. NB-64 interferes the gp41 six-helix bundle formation and blocks virus fusion.

The 2F5 epitope, a peptide gp41 (659-671), encompasses the complete sequential epitope recognized by one of the three broadly neutralizing antibodies against a wide range of primary HIV-1 isolates. This epitope is uniquely sequential and is identified by the 2F5 antibodies [1] [2].

C34 peptide, also referred to as HR2, is a biologically active peptide integral to the helical region of HIV's gp41 and is specifically the C-terminal heptad repeat 2 (HR2), denoted as the C helix or C peptide. It functions as a potent inhibitor of HIV-1 fusion, thereby impeding the virus's entry into cells via membrane fusion.

N36 peptide, an (HIV-1 gp41 fusion peptide), exhibits biological activity.

ELDKWA, a highly conserved sequence of amino acids located on the ecto-domain of gp41, serves as the epitope for mAb 2F5, a neutralizing monoclonal antibody against human immunodeficiency virus type 1 [1] [2].

DSPE-PEG1000-MPG is a PEG compound composed of DSPE and the peptide carrier (MPG). MPG is derived from the nuclear localization sequence (NLS) of the SV40 large T antigen and the fusion peptide domain of HIV-1 gp41. MPG efficiently delivers short oligonucleotides into cells, operating independently of endosomal pathways.

DSPE-PEG5000-MPG is a PEG compound composed of DSPE and a peptide carrier (MPG). MPG is derived from the nuclear localization sequence (NLS) of the SV40 large T antigen and the fusion peptide domain of HIV-1 gp41. This compound effectively delivers short oligonucleotides into cells independently of the endosomal pathway.

Theaflavin 3,3′-digallate (Standard) is a reference standard for research and analysis in studies involving Theaflavin 3,3′-digallate. Theaflavin 3,3'-digallate, a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it reduces tumor angiogenesis by downregulating HIF-1αand VEGF.

Trilobatin (Standard) is a reference standard for research and analysis in studies involving Trilobatin. Trilobatin (P-Phlorizin) has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially inhibits the lipopolysaccharide (LPS)-induced inflammatory response by suppressing the NF-κB signaling pathway.Trilobatin shows a strong inhibitory activity against α-glucosidase and a moderate inhibitory activity against α-amylase for management of postprandial hyperglycemia with less side effect.

Myriceric acid B is a potent HIV-1 entry inhibitor targeting gp41 and a lead compound for developing novel anti-HIV-1 drugs. It scavenges DPPH free radicals with an IC50 value of 21.8 μM, inhibits aromatase activity with an IC50 value of 6.8 μM, and exhibits cytotoxic activity towards the MOLT-3 cell line with an IC50 value of 3.9 μM.

MPG, a 27-amino acid peptide compound, is derived from the fusion peptide domain of HIV-1 gp41 and the nuclear localisation sequence of SV40 large T antigen. As a potent delivery agent, MPG enables efficient and widespread transport of nucleic acids and oligonucleotides into cultured cells.

VIRIP (human α1-AT(353-372)) serves as an inhibitor of HIV-1. It impedes HIV-1 entry by binding to the gp41 fusion peptide, making it useful in virus research.

N36Mut(e,g) is an HIV fusion peptide inhibitor targeting gp41. It functions by disrupting the formation of the homotrimeric coiled coil of the N-terminal helix in the pre-hairpin intermediate, leading to the creation of a heterotrimer.

soVIRIP is an antiviral peptide with an IC50 of 1.2 μM against HIV-1. It binds to the HIV-1 GP41 fusion peptide, thereby inhibiting viral fusion and blocking entry into host cells. soVIRIP demonstrates broad-spectrum anti-HIV-1 activity and shows no toxicity in zebrafish models. It is applicable in viral infection research.