gp41

Trilobatin (P-Phlorizin) has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentially inhibits the lipopolysaccharide (LPS)-induced inflammatory response by suppressing the NF-κB signaling pathway.Trilobatin shows a strong inhibitory activity against α-glucosidase and a moderate inhibitory activity against α-amylase for management of postprandial hyperglycemia with less side effect.

Theaflavin 3,3'-digallate, a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it reduces tumor angiogenesis by downregulating HIF-1αand VEGF.

Myriceric acid B is a potent HIV-1 entry inhibitor targeting gp41 and a lead compound for developing novel anti-HIV-1 drugs. It scavenges DPPH free radicals with an IC50 value of 21.8 μM, inhibits aromatase activity with an IC50 value of 6.8 μM, and exhibits cytotoxic activity towards the MOLT-3 cell line with an IC50 value of 3.9 μM.