gp41

HIV-1 env Protein gp41 (1-23) amide (isolates BRU JRCSF) is a polypeptide molecule with the sequence AVGIGALFLGFLGAAGSTMGARS-NH2.

HIV (gp41) Fragment AVGIGA is a polypeptide molecule with the sequence AVGIGA.

The 2F5 epitope, a peptide gp41 (659-671), encompasses the complete sequential epitope recognized by one of the three broadly neutralizing antibodies against a wide range of primary HIV-1 isolates. This epitope is uniquely sequential and is identified by the 2F5 antibodies [1] [2].

C34 peptide, also referred to as HR2, is a biologically active peptide integral to the helical region of HIV's gp41 and is specifically the C-terminal heptad repeat 2 (HR2), denoted as the C helix or C peptide. It functions as a potent inhibitor of HIV-1 fusion, thereby impeding the virus's entry into cells via membrane fusion.

N36 peptide, an (HIV-1 gp41 fusion peptide), exhibits biological activity.

ELDKWA, a highly conserved sequence of amino acids located on the ecto-domain of gp41, serves as the epitope for mAb 2F5, a neutralizing monoclonal antibody against human immunodeficiency virus type 1 [1] [2].

MPG, a 27-amino acid peptide compound, is derived from the fusion peptide domain of HIV-1 gp41 and the nuclear localisation sequence of SV40 large T antigen. As a potent delivery agent, MPG enables efficient and widespread transport of nucleic acids and oligonucleotides into cultured cells.

N36Mut(e,g) is an HIV fusion peptide inhibitor targeting gp41. It functions by disrupting the formation of the homotrimeric coiled coil of the N-terminal helix in the pre-hairpin intermediate, leading to the creation of a heterotrimer.