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By Target- Apoptosis
- Ras(1)
- Transferase(1)
- Others(2)
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Results for "
fti277
" in TargetMol Product Catalog- Inhibitors & Agonists3
FTI-277 hydrochloride
FTI 277 HCl
T2700180977-34-8
FTI-277 hydrochloride (FTI 277 HCl) is an effective and specific farnesyltransferase (FTase) inhibitor (IC50: 500 pM); this selectivity is about 100-fold than the closely related GGTase I.
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FTI 277 TFA
T412121217447-06-7
FTI 277 TFA is a prodrug form of FTI 276 that inhibits farnesyltransferase (FTase) (IC50 = 0.5 nM). Inhibits H-Ras and K-Ras processing in whole cells (IC50 values are 0.1 and 10μM respectively) and disrupts constitutive H-Ras-specific activation of MAPK. Causes significant antiproliferative effects in human malignant glioma cells and many other tumor cell lines.
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