fmoc-val-cit-pab

Fmoc-Val-Cit-PAB is a linker used for antibody-drug-conjugation (ADC).

Fmoc-Val-Cit-PAB-Duocarmycin TM is a drug-linker conjugate intended for antibody-drug conjugation (ADC), employing the antitumor antibiotic Duocarmycin TM and connected via the linker Fmoc-Val-Cit-PAB.

Fmoc-Val-Cit-PAB-MMAE is consisted of the ADCs linker (Fmoc-Val-Cit-PAB) and potent tubulin inhibitor (MMAE). Fmoc-Val-Cit-PAB-MMAE is a drug-linker conjugate for ADC.

Fmoc-Val-Cit-PAB-PNP is a linker used in Antibody-Drug Conjugation (ADC).

Fmoc-D-Val-Cit-PAB is a cleavable linker used in antibody-drug conjugation (ADC).

Fmoc-Val-D-Cit-PAB, a cleavable linker, is designed for use in antibody-drug conjugation (ADC).

Fmoc-D-Val-D-Cit-PAB is a cleavable linker used for antibody-drug conjugation (ADC).

Fmoc-Gly3-Val-Cit-PAB is a cleavable linker used in the assembly of antibody-drug conjugates (ADCs).

Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP is a cleavable linker used in antibody-drug conjugate (ADC) synthesis, enabling the attachment and controlled release of therapeutics from antibodies [1].

Fmoc-Gly3-Val-Cit-PAB-PNP, a four-unit PEG cleavable linker, is utilized in the creation of antibody-drug conjugates (ADCs) [1].

Fmoc-PEG6-Val-Cit-PAB-OH is a cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzyl alcohol on PAB can be utilized to attach reactive groups (e.g., PNP) for drug payload conjugation. The Fmoc protecting group is removable with piperidine, revealing a primary amine for amide bond formation in conjugation reactions. The Val-Cit-PAB segment is cleaved by cellular proteases, enabling efficient payload release into cells.

Fmoc-PEG2-Val-Cit-PAB-OH is a cleavable ADC linker that features a Boc-protected amine, hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzyl alcohol on the PAB can be used for conjugating reactive groups (e.g., PNP) to attach a payload. The Fmoc protecting group is removable with piperidine, revealing a primary amine for amide bond formation in conjugation reactions. The Val-Cit-PAB segment is cleaved by cellular proteases to efficiently release the payload inside cells.

Fmoc-PEG4-Val-Cit-PAB-OH is an enzyme-cleavable ADC linker that incorporates a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzyl alcohol on PAB can be used to attach reactive groups (such as PNP) for drug payload conjugation. The Fmoc protecting group can be removed with piperidine to expose a primary amine, facilitating amide bond formation. Val-Cit-PAB is cleaved by cellular proteases to efficiently release the payload inside cells.