fin56

FIN56 is an iron death-specific inducer that binds to and activates squalene synthase, inducing ferroptosis by triggering GPX4 degradation. FIN56 can be used in studies of ferroptosis regulatory mechanisms, autophagy-ferroptosis crosstalk, and tumor therapy.

Ferroptosis-IN-8 (Compound B4) is a potent and specific small molecule inhibitor of ferroptosis, demonstrating a half-maximal inhibitory concentration (IC50) of 40.49 nM. it suppresses RSL3- or FIN56-induced ferroptosis through robust antioxidant mechanisms, alleviates models of hepatorenal injury, and shows significant potential in preventing a spectrum of ferroptosis-related diseases.

Ferroptosis-IN-22 is a selective inhibitor of ferroptosis, which functions by targeting NCOA4 and disrupting its interaction with ferritin, exhibiting an EC50 of 520 nM and a Kd value of 0.78 μM. It effectively inhibits ferroptosis induced by various agents (RSL3, Erastin, ML210, FIN56) but does not inhibit cell necrosis induced by H2O2 or apoptosis induced by STS. Additionally, Ferroptosis-IN-22 significantly ameliorates Concanavalin A-induced acute liver injury and can be used in the study of ferroptosis-related diseases.