filovirus

Vorinostat (SAHA) is a pan-histone deacetylase (HDAC) inhibitor (IC50=10 nM) with inhibitory activity against HDAC1/2/3/6/7/11. Vorinostat has antitumor activity, induces cell differentiation, blocks the cell cycle and induces apoptosis.

Aloperine exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties.

SP187 (MON-DNJ) is a host-targeted iminosugar. It has anti-filovirus infection activity.SP187 is used for therapeutic use against influenza and dengue viruses.

Cephaeline hydrochloride, a phenolic alkaloid found in Indian Ipecac, effectively inhibits the infection of viruses ZIKV and EBOV.

Retro-2 (2-{[(5-methyl-2-thienyl)methylene]amino}) is a plant toxin ricin inhibitor, itprotects HeLa cells against Ricin, Stx1 and Stx2, selectively blocks retrograde toxin trafficking at the early endosome-TGN (trans-Golgi network) interface.

Cephaeline was highly active against protected primary CLL cells (relative IC50's 35nM ) and acted by repressing HIF-1α± and disturbing intracellular redox homeostasis.

R 59-022 (DKGI-I) is a diacylglycerol kinase (DGK) inhibitor and a 5-HT Receptor antagonist that blocks filovirus internalization in host cells. R 59-022 activates protein kinase C (PKC), inhibits intestinal smooth muscle contractility, and enhances O2- production induced by 1-oleoyl-2-acetylglycerol.

Antiviralagent 66 (Compound 60) serves as an inhibitor of filoviruses (Filovirus), effectively suppressing pseudoviruses of Ebola, Marburg, Zaire, Sudan, Bundibugyo, Reston, and Tai Forest, with EC50 values of 0.16, 2.24, 0.16, 0.89, 0.21, 0.21, and 0.11 μM, respectively.

Chlorphenoxamine hydrochloride is an antihistamine and anticholinergic agent that also acts as a GPCR antagonist. It can suppress various deadly viral diseases such as SARS-CoV, MERS-CoV, Ebola virus (EBOV), and malaria. The compound exhibits anti-filovirus activity against both EBOV and Marburg virus (MARV), with IC50 values of 1.1 μM and 6.2 μM, respectively. Chlorphenoxamine hydrochloride is utilized in research related to allergic disorders, urticaria, viral diseases, and Parkinson's disease.

Antiviralagent 75 (example D26) is an inhibitor of the Ebola virus (EBOV) and Bundibugyo Ebola virus (BDBV), with EC50 values of 0.11 μM and 0.75 μM, respectively. It is useful for research on filovirus infections.

Eritoran, a Toll-like receptor 4 (TLR4) antagonist, effectively protects mice from lethal infections caused by viruses such as the Ebola virus (EBOV) and Marburg virus (MARV). By decreasing granulocytosis levels, Eritoran may reduce the severity of cytokine storms, thereby inhibiting the pathogenesis of filovirus infections [1].

Maftivimab is a human monoclonal antibody targeting the glycoprotein (GP) of Zaire ebolavirus (EBOV). It is important to note that Maftivimab is one of the three core components of the Inmazeb cocktail (comprising Atoltivimab, Maftivimab, and Odesivimab, which target distinct, non-overlapping epitopes). Maftivimab neutralizes viral virulence by specifically binding to the viral surface glycoprotein, effectively blocking the process of viral entry into host cells. It has been approved for the treatment of Zaire ebolavirus infection, showing significant efficacy in reducing mortality rates and clearing viral loads.