fb23

FB23 directly binds to FTO and selectively inhibits FTO's m6A demethylase activity. (FTO, an mRNA N6-methyladenosine (m6A) demethylase, was reported to promote leukemogenesis.)

FB23-2 is a potent and selective inhibitor of the mRNA N6-methyladenosine (m6A) demethylase FTO with an IC50 of 2.6 μM.

FB231 is a Parkin activator that can induce mild mitochondrial stress, resulting in impaired mitochondrial function and activation of the integrated stress response (ISR). It reduces the threshold for PINK1/Parkin-mediated mitophagy induced by mitochondrial toxins and disrupts iron-dependent pathways. FB231 is applicable in research on neurological disorders, including Parkinson's disease.

ZLD115 (compound 44), a derivative of FB23, functions as an inhibitor of the Fat Mass and Obesity-associated Protein (FTO) and demonstrates antiproliferative properties as an antileukemic agent against leukemic cell lines [1].