estriol

Estriol (Oestriol) is a hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA.

Estriol 3-β-D-glucuronide is a metabolite of estriol . It is formed from estriol by the UDP-glucuronosyltransferase (UGT) isoform UGT1A10. Estriol 3-β-D-glucuronide binds to basolateral and canalicular liver plasma membranes with Kd values of 85 and 164 μM, respectively. It competitively inhibits the hydrolysis of 4-methylumbelliferyl-β-D-glucuronide and is a substrate for hydrolysis by Klotho-human IgG1 Fc protein (KLFc).

Estriol-3-glucuronide, a natural compound found in urine, is also present in amniotic fluid during normal pregnancy [1][2].

Estriol 16α-(β-D-glucuronide), an endogenous metabolite found in urine, is utilized in pregnancy research [1] [2].

Estriol 3-sulfate is a useful organic compound for research related to life sciences and the catalog number is T124799.

Estriol 17-sulfate is a useful organic compound for research related to life sciences and the catalog number is T124856.

Estriol 3,17-dihexanoate is a useful organic compound for research related to life sciences and the catalog number is T126484.

Estriol-D3 is a deuterated compound of Estriol. Estriol (T1571) has a CAS number of 50-27-1. Estriol (T1571) is a hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol (T1571) is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA.

Estriol (Standard) is the standard substance of Estriol, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Estriol (Standard) is a hydroxylated metabolite of estradiol or estrone and is therefore used in endocrine analysis and steroid metabolism research systems to investigate estrogen biosynthesis, metabolic conversion pathways, and pregnancy-associated hormone regulation in biochemical models.

Estriol-[13C3] (Standard) is a reference standard of Estriol-[13C3] intended for quantitative analysis, quality control, and related biochemical research applications.

Estriol-D3 (Standard) is a reference standard of Estriol-D3 intended for quantitative analysis, quality control, and related biochemical research applications. Estriol-d3 is a deuterated compound of Estriol. Estriol has a CAS number of 50-27-1. Estriol is a hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA.

Estriol impurity 2 (3-Methoxyestriol) is an impurity of Estriol.

Actriol (Epiestriol) is always used as Glucocorticoid Receptor agonist.

Estrone-D4 is a deuterated compound of Estrone. Estrone (T1009) has a CAS number of 53-16-7. Estrone (T1009) is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women.

16α-Hydroxy-17β-Estradiol-2,4-D2 (Standard) is a reference standard of 16α-Hydroxy-17β-Estradiol-2,4-D2 intended for quantitative analysis, quality control, and related biochemical research applications. 16α-Hydroxy-17β-estradiol-2,4-d2 is a deuterated compound of Estriol. Estriol has a CAS number of 50-27-1. Estriol is a hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA.

Nylestriol (LY 49825) is an agonist of estrogen receptor.

17-Epiestriol is an endogenous metabolite of estrone formed via a 16α-hydroxy estrone intermediate followed by reduction of the C-17 ketone, and it binds estrogen receptor α and estrogen receptor β with relative binding affinities of 29 and 80 compared with 17β-estradiol, supporting its relevance in studies of estrogen signaling, metabolism, and receptor selectivity.

Estradiol impurity 9 (9,11-Didehydrooestriol) is an impurity of Estradiol.

Mytatrienediol is a synthetic, steroidal, weak estrogen and estrogen ether derived from estriol.

16α-Hydroxyestrone is an important metabolite of estradiol, with important application value in basic research of metabolic diseases. It acts as an inhibitor of Breast cancer cell line MDA-MB-175-VII.

16α-hydroxy Dehydroepiandrosterone (16α-OH-DHEA) is a neurosteroid found in the brain, a precursor to placental estriol biosynthesis.

16α-Hydroxy-17β-estradiol-2,4-D2 is a deuterated compound of 16α-Hydroxy-17β-estradiol (TMSM-1124). Estriol has a CAS number of 50-27-1. Estriol is a hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA.

16α-Hydroxyestrone (Standard) is a reference standard for research and analysis in studies involving 16α-Hydroxyestrone. The naturally-occurring estrogens are estrone , estradiol , and estriol . 16α-hydroxy Estrone (16α-OHE1) is a hydroxylated metabolite of E1 as well as an interconversion product with E2. E1 is 16α-hydroxylated by cytochrome P450 (CYP) isoforms, including CYP1A1, CYP3A5, CYP3A4, and CYP3A7, with CYP3A5 being breast-specific. 16α-OHE1 is sulphatized or glucuronidated before excretion. It is increased in rheumatoid arthritis and decreased by physical activity. Unlike the parent estrogens and other hydroxylated metabolites of E1, 16α-OHE1 binds covalently and persistently activates estrogen receptors. In addition, this metabolite increases cell proliferation and does not suppress TNF-α secretion, whereas other estrogen metabolites are not pro-proliferative and have marked effects on TNF-α secretion. The levels of 16α-OHE1 are increased in some forms of hormone therapy. Because hormone therapy increases breast cancer risk, 16α-OHE1 has been implicated as a risk factor for breast cancer, although supportive data remains elusive.