epithelial sodium channel (enac)

Triamterene is a barosensitive epithelial sodium channel (ENaC) blocker with a diuretic effect. It can also act as an inhibitor of the TGR5 receptor, reducing GLP-1 secretion and cAMP level increases induced by TGR5 activation in a dose-dependent manner.

Camostat mesylate (FOY-S980) is a trypsin-like protease inhibitor and inhibits airway epithelial sodium channel (ENaC) function.

BI 1265162 is a potent inhibitor of the epithelial sodium channel (ENaC), playing a crucial role in cystic fibrosis research.

NVP-QBE170 is a selective epithelial sodium channel (ENaC) inhibitor with an IC50 of 57.5 nM. It effectively suppresses ENaC function in human bronchial epithelial cells (HBEC), with a prolonged duration of action. NVP-QBE170 significantly decreases ENaC activity in guinea pig airway models and can be utilized for hyperkalemia research.

PA1 2HCl is a blocker of photoswitchable epithelial sodium channel (ENaC). PA1 2HCl enables the optical control of ENaC channels, in particular the δβγ isoform, by switching between blue and green light, or by turning on and off blue light.

Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane vesicles.

Amiloride (MK-870) is an inhibitor of the epithelial sodium channel (ENaC) and the urokinase-type plasminogen activator receptor (uPAR). It also acts as a blocker of the polycystin-2 (PC2; TRPP2) channel.

Triamterene (Standard) is the standard substance of Triamterene, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Triamterene is a barosensitive epithelial sodium channel (ENaC) blocker with a diuretic effect. It can also act as an inhibitor of the TGR5 receptor, reducing GLP-1 secretion and cAMP level increases induced by TGR5 activation in a dose-dependent manner.