egta

Ethylenebis(oxyethylenenitrilo)tetraacet is a diether that is ethylene glycol in which the hydrogens of the hydroxy groups have been replaced by 2-[bis(carboxymethyl)amino]ethyl group respectively.

EGTA-AM (EGTA Acetoxymethyl ester) is a calcium chelator, a metabolic biomarker of early-onset preeclampsia and late-onset preeclampsia.

EGTA tetrasodium is a specialized chelating agent for calcium ions. At physiological pH (7.4), it exhibits a dissociation constant (Kd) of 60.5 nM, indicating a high specificity for Ca2+ over Mg2+. Additionally, EGTA tetrasodium significantly inhibits the substrate adhesion capability of inflammatory macrophages.

Pegtarazimod (RLS-0071) inhibits the complement system through both the classical and lectin pathways. It suppresses myeloperoxidase (MPO) activity, leading to reduced ROS production, and decreases the formation of neutrophil extracellular traps (NET). Pegtarazimod exhibits anti-inflammatory properties and is applicable in the study of acute graft-versus-host disease.

ICILIN (AG-3-5) is a synthetic TRPM8 ion channel super-agonist.

DMNPE-4 AM-caged-calcium, a photolabile analogue of EGTA, is a highly efficient Ca2+-selective cage. At pH 7.2 and pH 7.4, its Kd for Ca2+ is measured at 48 nM and 19 nM, respectively. Upon photolysis, DMNPE-4 AM-caged-calcium exhibits a decreased affinity for Ca2+ (~2 nM Kd).