eef1a2

Metarrestin (ML246) is a first-in-class perinucleolar compartment inhibitor with a favorable PK profile, which effectively suppresses metastasis. Metarrestin disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription, at least in part by interacting with the translation elongation factor eEF1A2.

Aplidine possesses antiviral activity against SARS-CoV-2(IC90 = 0.88 nM). Aplidine is a potent anti-cancer agent by targeting eukaryotic translation elongation factor 1 Alpha 2(EEF1A2, Kd = 80 nM).

EEFA2-IN-1 is a potent covalent inhibitor of EEF1A2, exhibiting selective antiproliferative activity against osteosarcoma (OS) cells. It induces apoptosis by inhibiting EEF1A2 and downregulating the AKT signaling pathway. In xenograft mouse models, EEFA2-IN-1 suppresses tumor growth, making it a useful compound for osteosarcoma (OS) research.