echinocandin

Rezafungin (SP-3025, Biafungin) is a natural product echinocandin and a 1,3-β-D-glucan synthase inhibitor with broad-spectrum antifungal activity, high tissue penetration, and a long half-life, used for the treatment of candidemia and invasive candidiasis.

Echinocandin B is a cyclic hexapeptide echinocandin antibiotic from Aspergillus nidulans var. echinulatus . It attacks the cell wall of fungi by inhibiting beta-1,3-glucan synthesis.

Echinocandin B nucleus (A-30912 A nucleus) is the reaction product catalyzed by Echinocandin B decarboxylase. It serves as an intermediate in the semisynthetic production of antifungal agents.

ECBN HCL (A-30912A nucleus hydrochloride) is the reaction product catalyzed by Echinocandin B (ECB) deacylase.

Tetrahydroechinocandin B is a cyclic hexapeptide containing a fatty acyl side chain. It also inhibits 1,3-beta-D-glucan synthesis.

Rezafungin acetate (Biafungin acetate) is a echinocandin with antimicrobial activity that inhibits 1,3-β-D-glucan synthase. It can be used for research on invasive fungal diseases in hematopoietic and bone marrow transplant recipients.

Micafungin sodium (FK 463) is the sodium salt form of micafungin, a semi-synthetic echinocandin derived from a natural product of the fungus Coleophoma empetri with antifungal activity.

Caspofungin Acetate (MK 0991) is the acetate salt of an antimycotic echinocandin lipopeptide, semisynthetically derived from a fermentation product of the fungus Glarea lozoyensis. This agent is active against Aspergillus and Candida species.

Deoxymulundocandin is an echinocandin type antifungal antibiotic from Aspergillus sydowii.

FR901379 is an echinocandin-like antifungal lipopeptide.1 It is active against C. albicans, C. krusei, C. tropicalis, C. utilis, A. fumigatus, and A. niger fungi (IC50s = <0.003-1.9 μg/ml). FR901379 is protective against C. albicans infection in mice (ED50 = 1.1 mg/kg). It also reduces the number of pulmonary cysts and trophozoites in a mouse model of P. carinii infection. |1. Fujie, A., Iwamoto, T., Sato, B., et al. FR131535, a novel water-soluble echinocandin-like lipopeptide: Synthesis and biological properties. Bioorg. Med. Chem. Lett. 11(3), 399-402 (2001).

FR179642 is the cyclic peptide nucleus of the lipopeptide antifungal FR901379 and an intermediate in the synthesis of the echinocandin antifungal FK463 .1,2 1.Tomishima, M., Ohki, H., Yamada, A., et al.FK463, a novel water-soluble echinocandin lipopeptide: Synthesis and antifungal activityJ. Antibiot. (Tokyo)52(7)674-676(1999) 2.Ueda, S., Shibata, T., Ito, K., et al.Cloning and expression of the FR901379 acylase gene from Streptomyces sp. no. 6907J. Antibiot. (Tokyo)64(2)169-175(2011)

FR179642 is a key intermediate in the synthesis of the antifungal drug Micafungin and also corresponds to the cyclic peptide core structure of the lipopeptide natural product FR901379. FR179642 belongs to the structural framework of echinocandin-class antifungal compounds and serves as an important reference in the structural optimization and synthesis of β-1,3-glucan synthase inhibitors.

Anidulafungin (Ecalta) (LY303366) is an echinocandin derivative used as an antifungal drug. It inhibits glucan synthase activity.

Puupehenone is a natural heat shock protein 90 (Hsp90) inhibitor, potentiating the echinocandin drug caspofungin in caspofungin-resistant fungal pathogens, blocking the induction of caspofungin-responding genes required for the adaptation to cell wall stress through the cell wall integrity (CWI) pathway.

Caspofungin is a cyclic lipopeptide echinocandin and beta-(1,3)-D-glucan synthase inhibitor that is used to treat internal or systemic mycoses.

Aminocandin (HMR 3270), a water-soluble echinocandin class antifungal agent, exhibits exceptional efficacy against Aspergillus and Candida species [1].

Anidulafungin-d11 is the deuterium-labeled form of Anidulafungin. Anidulafungin is a novel semisynthetic echinocandin with antifungal (antifungal) potency.

Caspofungin Acetate (Standard) is a reference standard for research and analysis in studies involving Caspofungin Acetate. Caspofungin Acetate (MK 0991) is the acetate salt of an antimycotic echinocandin lipopeptide, semisynthetically derived from a fermentation product of the fungus Glarea lozoyensis. This agent is active against Aspergillus and Candida species.

Micafungin sodium (Standard) is a reference standard for research and analysis in studies involving Micafungin sodium. Micafungin sodium (FK 463) is the sodium salt form of micafungin, a semi-synthetic echinocandin derived from a natural product of the fungus Coleophoma empetri with antifungal activity.