docosatrienoic acid

Docosatrienoic acid is a rare omega-3 fatty acid; Ki value is 5×M, which inhibits the binding of LTB4 to porcine neutrophil membrane.

(±)13,14-EDT, an oxylipin metabolite derived from adrenic acid through the cytochrome P450 (CYP) pathway, acts as a potent activator of large-conductance calcium-activated potassium channels (KCa1.1/BK) in isolated rat coronary small arterial smooth muscle cells at 50 nM, promoting dilation. Additionally, it induces arteriole dilation in isolated porcine samples with an EC50 of 12 pM and relaxes isolated bovine coronary arteries previously contracted by TP receptor agonist U-46619.

(±)16,17-EDT, an oxylipin metabolite of adrenic acid produced through the cytochrome P450 (CYP) pathway, effectively induces dilation in isolated porcine arterioles (EC50 = 11 pM) and promotes relaxation of isolated bovine coronary arteries previously contracted by the TP receptor agonist U-46619.

cis-13,16,19-Docosatrienoic acid methyl ester is an ester form of docosatrienoic acid, a rare ω-3 fatty acid. This compound is not easily detectable in the normal phospholipid polyunsaturated fatty acid pool and at a concentration of 5 μM, it inhibits the binding of [3H]-LTB4 to porcine neutrophils. The methyl ester form exhibits greater lipid solubility than the free acid, potentially making it more suitable for certain formulations.

(±)7,8-DiHDoTrE ((±)7,8-DHDT) is a type of dihydroxy-docosatrienoic acid (DHDT).