dhcr24

Azacosterol (Diazasterol) is a DHCR24 inhibitor.Azacosterol undergoes a series of reactions in cortical neurons following oral or intraperitoneal administration.

SFI003 is a novel SRSF3 inhibitor that exerts anticancer activity against colorectal cancer by modulating the SRSF3 DHCR24 ROS axis and driving apoptosis in CRC cells through the SRSF3 DHCR24 reactive oxygen species (ROS) axis.

E2012 is a γ-secretase modulator (GSM). E2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at Alzheimer's disease by reduction of amyloid β-42, and induces cataract following repeated doses in the rat.

SH-42 is a human Δ24-dehydrocholesterol reductase (DHCR24) inhibitor (IC50: 42 nM) that is selective and highly potent in inducing an increase in plasma desmethylferricinol levels.