dhcr24

SH-42 is a human Δ24-dehydrocholesterol reductase (DHCR24) inhibitor (IC50: 42 nM) that is selective and highly potent in inducing an increase in plasma desmethylferricinol levels.

Azacosterol (Diazasterol) is a DHCR24 inhibitor.Azacosterol undergoes a series of reactions in cortical neurons following oral or intraperitoneal administration.

SFI003 is a small-molecule inhibitor and an SRSF3 inhibitor with favorable pharmacokinetic properties, bioavailability, and tumor distribution capacity, inducing apoptosis in colorectal cancer cells through the SRSF3/DHCR24/ROS axis and exhibiting potent antitumor activity.

E2012 is a γ-secretase modulator (GSM). E2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at Alzheimer's disease by reduction of amyloid β-42, and induces cataract following repeated doses in the rat.