dbco-peg1

DBCO-PEG1, a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules and enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-PEG1-acid is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-PEG1-amine is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, and facilitates selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-PEG1-NH-Boc is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-PEG1-NHS ester is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands necessary for PROTAC molecule formation. This linker enables selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

DBCO-PEG10-DBCO is a PEG-based linker used in PROTACs, joining two essential ligands needed to form PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-PEG12-acid is a PEG-based linker for PROTACs that connects two essential ligands, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

DBCO-PEG12-NHS ester is a PEG-based PROTAC linker for synthesising PROTAC molecules, whose DBCO group undergoes click chemistry with azide-containing molecules.

DBCO-PEG13-DBCO, a PEG-based linker for PROTACs, connects two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-PEG13-NHS ester is a PEG-type PROTAC linker useful in the synthesis of PROTAC molecules. This compound acts as a click chemistry reagent and contains a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing an azide group.

DBCO-PEG2-C2-acid, serving as an ADC Linker, is utilized in the synthesis of Antibody-Drug Conjugates (ADCs).

DBCO-PEG16-NHS ester is a PEG derivative composed of DBCO, PEG units, and an NHS ester. The NHS ester can react with amino acids or other amine-containing molecules. The DBCO group in DBCO-PEG16-NHS ester can engage in a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with azide-containing molecules.

Azido-PEG1 is a PEG-like PROTAC linker for the synthesis of PROTAC molecules.Azido-PEG1 contains an Azide moiety and can undergo click chemistry reaction CuAAc with molecules containing an Alkyne moiety or SPAAC with molecules containing a DBCO or BCN moiety.

DBCO-C-PEG1 is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, facilitating selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

Boc-PEG1-PPG2-C2-azido is a PROTAC linker of the PEG class, utilized in PROTAC molecule synthesis. This compound acts as a click chemistry reagent containing an azide group, enabling copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Additionally, it participates in strain-promoted azide-alkyne cycloaddition reactions (SPAAC) with molecules containing DBCO or BCN groups.

Lenalidomide 4'-PEG1-azide (Compound 4g) is an azide derivative of lenalidomide. This compound includes a cereblon ligand and a linker. It functions as a click chemistry reagent, featuring an azide group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAC) with molecules containing alkyne groups, and also participates in strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Azido-PEG1-Val-Cit-PABC-PNP, a 1 unit PEG ADC linker, is utilized in the development of antibody-drug conjugates (ADCs) [1]. This compound serves as a click chemistry reagent featuring an Azide group, facilitating copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules bearing Alkyne groups. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

DPPE-PEG1-azide (DPPE-PEG1-N3) is a PEG-modified lipid featuring an azide group (azide). It can participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) with molecules containing alkyne groups. Additionally, it can undergo strain-promoted alkyne-azide cycloaddition reactions (SPAAC) with molecules that have DBCO or BCN groups.

DSPE-PEG1-azide (DSPE-PEG1-N3) is a lipid-containing azide compound that can form micelles for use as drug delivery nanoparticles. It serves as a reagent for click chemistry and features azide groups that participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Additionally, it undergoes strain-promoted azide-alkyne cycloaddition reactions (SPAAC) with molecules containing DBCO or BCN groups.

Azide-PEG1-Desthiobiotin is a PEG derivative comprising desthiobiotin, a single PEG unit, and an azide group (azide). Biotin within this compound can form a stable non-covalent bond with streptavidin (Streptavidin). The azide group facilitates copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing alkyne groups. Additionally, it can undergo strain-promoted azide-alkyne cycloaddition reactions (SPAAC) with molecules that have DBCO or BCN groups.