cyclic somatostatin

Cyclic somatostatin (SRIF-14) is a cyclic tetradecapeptide that regulates various endocrine and nervous system functions.

Cyclic somatostatin Acetate(38916-34-6(free base)) (Somatostatin-14) is a cyclic tetradecapeptide regulating many endocrine and nervous system functions.

San 201-456 is a cyclic hexapeptide somatostatin analog.

Sdz 204-090 is a cyclic octapeptide analog of somatostatin.

Angiopeptin TFA, a cyclic octapeptide analogue of somatostatin, acts as a partial agonist at sst 2/sst 5 receptors, with IC50 values of 0.26 nM and 6.92 nM, respectively. It effectively inhibits the release of growth hormone and the production of insulin-like growth factor-1 (IGF-1), and either inhibits adenylate cyclase activity or promotes extracellular acidification. Angiopeptin TFA shows promise for use in coronary atherosclerosis research [1] [2].

[Nle8] Somatostatin (1-28), a derivative of somatostatin (1-28) with norleucine (Nle) substituting for methionine at position 8, enhances amylase release and elevates cyclic AMP levels in pancreatic acini [1].

Octreotide, a cyclic SSTR agonist, serves as the cyclic Somatostatin Receptor SSTR agonist [1].

PACAP (1-38) free acid is a deamidated PACAP (1-38) derived from humans, sheep, and rats. PACAP (1-38) free acid can activate the human PAC1 receptor and promote cyclic adenosine monophosphate synthesis in NS‑1 neuroendocrine cells and non-neuroendocrine HEK293 cells.

BIM-23027 is a selective sst 2 receptor agonist (EC 50 = 0.32 nM) with effects analogous to the cyclic tetradecapeptide somatostatin (SRIF). It promotes dopamine release through a Glu-dependent mechanism [1] [2].

CYN 154806 TFA is a cyclic octapeptide and an effective selective somatostatin sst2 receptor antagonist. For the recombinant sst2, sst1, sst3, sst4 and sst5 receptors, the pIC50 values are 8.58, 5.41, 6.07, 5.76 and 6.48, respectively.

[Nle8] Somatostatin (1-28) TFA is a derivative of somatostatin (1-28) where methionine at position 8 is replaced with norleucine. This compound enhances the release of amylase and increases cyclic AMP in pancreatic acini.