cultures

9-Methoxycanthin-6-one has anti-tumour activity, exhibits cytotoxic activity towards KB, LU-1, LNCaP, HL-60 cancer cells and other human cancer cell lines with IC50 values around 1-4 μg/mL.

Vidarabine (Adenine Arabinoside) is a nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the VACCINIA VIRUS and varicella zoster virus.

3-(Methylthio)propionic acid (4-Thiapentanoic acid) is one of the metabolites of methionine (especially of D-methionine). Cultures of Streptomyces lincolnensis accumulated 3-methylthioacrylic acid in amounts directly related to the concentration of methionine in the medium. The first intermediate in the pathway may be the keto acid, which is then oxidatively decarboxylated to 3-methylthiopropionic acid.

Methyl jasmonate ((-)-Methyl jasmonate) is a hormone involved in plant signaling, inducing oxidative stress and accumulation of secondary metabolites in plant cells and organ cultures, and regulating the biosynthesis of other plant hormones. Methyl jasmonate induces plant defense responses against Andean lupin insects. Methyl jasmonate has anti-inflammatory activity.

Tylosin (Tylosine) is a macrolide antibiotic obtained from cultures of Streptomyces fradiae. The drug is effective against many microorganisms in animals but not in humans.

10-Isobutyryloxy-8,9-epoxythymol isobutyrate, a major constituent of Inula helenium and Inula royleana root cultures,

Obscurolide A1 is a butenolide isolated from Streptomyces viridochromogenes cultures that shows weak inhibitory activity against Ca2+/CaM-dependent and non-Ca2+/CaM-dependent phosphodiesterases in cattle.

N-hexanoyl-DL-Homoserine lactone (C6-HSL), isolated from bivalve larval cultures, degrades bacteria and inhibits lesions induced by the phytopathogenic fungus B. cinerea.N-hexanoyl-DL-Homoserine lactone participates in the bacterial N-acyl-homoserine lactone (AHL) community-sensing (QS) system. N-hexanoyl-DL-Homoserine lactone is involved in the N-acyl-homoserine lactone (AHL) community sensing (QS) system between bacteria.

Amphotericin B trihydrate, a polyene antibiotic derived from Streptomyces nodosus fermenter cultures, exhibits antileishmanial properties.

Calycosin (Cyclosin) acts as a selective estrogen receptor modulator. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Calycosin suppresses breast cancer cell growth via ERβ-dependent regulation of IGF-1R, p38 MAPK and PI3K/Akt pathways. Calycosin has antineoplastic effects against osteosarcoma through inducing apoptosis showing in vitro and in vivo investigations. Calycosin was shown to induce angiogenesis in human umbilical vein endothelial cell cultures (HUVEC) in vitro. Calycosin may be an effective skin-lightening agent that regulates the expression of melanogenic enzymes. Calycosin exhibited tyrosinase inhibitory activity with an IC(50) value of 38.4 microM.

(S)-3-(4-Hydroxyphenyl)-2-hydroxypropionic acid ((S)-3-(4-Hydroxyphenyl)lactic acid) (compound 1) is a metabolite found in the culture medium of Leuconostoc mesenteroides, exhibiting significant DPPH radical-scavenging and antioxidative activities.

Cladospirone bisepoxide, a metabolite isolated from fungal cultures, exhibits selective antibiotic activity against various bacteria and fungi, and at low concentrations, it inhibits the germination of Lepidium sativum [1].

Eremofortin A, a metabolite, can be isolated from Penicillium roqueforti cultures [1].

Urolithin D is a competitive and selective reversible antagonist of the EphA receptor, an ellagitannin colonic metabolite that inhibits EphA2 phosphorylation in prostate cancer cells, attenuates triglyceride accumulation in adipocytes and hepatocyte cultures, and may be used in the study of metabolic disorders.

Aculene D, a fungal metabolite, exhibits quorum sensing (QS) inhibitory effects on Chromobacterium violaceum CV026, significantly reducing violacein production in N-hexanoyl-l-homoserine lactone (C6-HSL) induced cultures of C. violaceum CV026 at sub-inhibitory concentrations [1].

Guignardone K, a meroterpene compound extracted from solid cultures of the endophytic fungus Guignardia sp., exhibits antifungal activity [1].

Sporidesmolide V, a cyclodepsipeptide, has been isolated from Pithornyces chartarum cultures [1].

Semicochliodinol, a compound that can be isolated from rice cultures of the fungus genus Chaetomium, has been identified [1].

Kanzonol D, a flavonoid derived from the hairy root cultures of Glycyrrhiza glabra [1], exhibits anti-inflammatory and anticancer properties by inhibiting nitric oxide production and suppressing NF-κB activation. It also shows potential in osteoblast differentiation, suggesting its utility in bone diseases.

Hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone is a neuroprotective agent that significantly mitigates glutamate-induced neurotoxicity in primary rat cortical cell cultures [1].

Tylosin (Standard) is the standard substance of Tylosin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Tylosin (Tylosine) is a macrolide antibiotic obtained from cultures of Streptomyces fradiae. The drug is effective against many microorganisms in animals but not in humans.

Dihydromonacolin L is a potent inhibitor of cholesterol biosynthesis that can be isolated from cultures of a Monascus niber mutant.

Paeonilactone C significantly protects primary cultures of rat cortical cells against H2O2-induced neurotoxicity.

Senecionine n-oxide is a major product of pyrrolizidine nucleic alkaloid biosynthesis in unusual root cultures of Trichoderma lucidum.Senecionine N-oxide (Senecionine oxide) has antitumor activity but induces hepatic sinusoidal obstruction syndrome.Senecionine n-oxide acts as a chelating tracer for N-oxide.