cp 248

OSIP-486823(CP248) is a novel and potent microtubule disruptor with affinity for both protein kinase G (PKG) and microtubules.

Exisulind (CP248) induces apoptosis through the activation of protein kinase G (PKG). Exisulind exhibits antineoplastic activity in solid tumour and haematological cancer cell lines and is an inhibitor of tumour growth in rodent models of colon, prostate, bladder, mammary and lung cancer.

Mesutoclax (ICP-248) (Compound 5) is a selective BCL-2 inhibitor with an IC50 of 1.54 nM, demonstrating weak activity against BCL-XL (IC50: >1000 nM). Mesutoclax (ICP-248) (Compound 5) inhibits the viability of RS4;11 cells with an IC50 of 2.75 nM and is therefore used in apoptosis and cancer cell biology research systems to investigate BCL-2–mediated survival signaling, intrinsic apoptotic pathway activation, and leukemia cell viability regulation.

CP-24879 hydrochloride (CP-24879 HCl), a Δ5D/Δ6D dual-inhibitor, can significantly reduce intracellular lipid accumulation and inflammatory injury in hepatocytes. CP-24879 hydrochloride exhibits superior antisteatotic and anti-inflammatory actions in fat-1 and ω-3-treated hepatocytes.