catb

Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.

Compound 10, Aminooxy CatB-LXR, constitutes an agent-linker conjugate for antibody-drug conjugates (ADC) [1].

DBCO-NHCO-PEG4-NHS ester is a DBCO-containing PEGylated active ester linker that combines NHS ester reactivity toward primary amines with strain-promoted azide-alkyne cycloaddition capability. It enables efficient bioconjugation through amide coupling and copper-free click reaction with azide groups. The PEG4 spacer provides hydrophilicity and tunable linker length, making it widely used in PROTAC and antibody-drug conjugate (ADC) construction.

SmCB1-IN-1 (Compound 2h) is an inhibitor of the Schistosoma mansoni cathepsin B1 (SmCB1) with a Ki of 0.05 μM. It demonstrates selectivity towards non-target human proteases, showing inhibition rates of 29% for CatB and 37% for CatL at 20 μM. At 1 μM, SmCB1-IN-1 inhibits 68% of Schistosoma mansoni.