can-508

CAN508 is a potent ATP-competitive CDK9/cyclin T1 inhibitor with an IC50 of 0.35 μM. It also competitively inhibits Cdk2-cyclin E with respect to ATP, with Ki and IC50 values of 13.3 μM and 20 μM, respectively. CAN508 exhibits a 38-fold selectivity for CDK9/cyclin T over other CDK/cyclin complexes. [Antitumor activity.]

BODIPY-labeled vitamin B12 is vitamin B12 conjugated with BODIPY fluorescent dye, which can be used to study the cellular metabolism and transport of vitamin B12 in live cells, with λex = 493 nm and λem = 508 nm.

RNF5 inhibitor inh-02 is a selective inhibitor of the ubiquitin ligase RNF5/RMA1, which can significantly rescue F508del-CFTR (cystic fibrosis transmembrane conductance regulator with a deletion at position 508 of phenylalanine) and regulate ATG4B and paxillin, making it useful for studying cystic fibrosis (CF).

13(18)-Oleanen-3-ol is a natural product of Cucurbita, Cucurbitaceae. The catalog number is TN1188 and the CAS number is 508-04-3. 13(18)-Oleanen-3-ol can be used as a reference standard.