c12200

C12-200 is a five-tail/branched ionizable cationic lipid that serves as a benchmark lipid material in RNA delivery, demonstrating exceptional performance in mRNA and siRNA lipid nanoparticle (LNP) formulations.

Arginine glutamate serves as a nitrogen donor in the synthesis of nitric oxide. Arginine glutamate promotes gastric emptying in rats and can be used in research on functional dyspepsia.

(S)-C12-200, the (S)-isomer of C12-200, is an ionizable cationic lipid and an auxiliary lipid. It is utilized in the formulation of lipid nanoparticles for mRNA delivery.

(R)-C12-200, an ionizable cationic lipid (pKa = 7.25) and isomer of C12-200, is utilized in forming lipid nanoparticles (LNPs) for delivering mRNA in vivo. When administered intravenously, LNPs containing (R)-C12-200 with mRNA encoding Cre recombinase result in a smaller increase in the percentage of tdTomato+ hepatocytes, endothelial cells, and Kupffer cells in the liver of Ai14 mice compared to LNPs with (S)-C12-200. Additionally, LNPs with (R)-C12-200 carrying mRNA for purine nucleoside phosphorylase (PNP), an E. coli enzyme that transforms fludarabine phosphate into the cytotoxic agent 2-fluoroadenine, prompt intratumoral PNP expression and diminish tumor volume in a FaDu head and neck squamous cell carcinoma (HNSCC) mouse xenograft model when fludarabine phosphate is co-administered.