brefeldin a

Brefeldin A (Cyanein) belongs to the class of macrolide antibiotics and is an ATPase inhibitor (IC50=0.2 μM). Brefeldin A can induce tumor cell differentiation and apoptosis, and also possesses autophagy inhibitory activity.

Brefeldin A 4-O-nicotinate (CHNQD-01228) is a dual inhibitor of Arf1 and BMX proteins with an IC50 value of 0.22 μM for T24 cell proliferation. It also suppresses T24 cell migration and colony formation in a dose-dependent manner, induces G1 phase arrest, and triggers apoptosis. By targeting BMX proteins, it inhibits the AKT/p-AKT and STAT3/p-STAT3 signaling pathways, while also inhibiting Arf1 proteins to eliminate bladder cancer stem cells and activate antitumor immunity, thus exhibiting anticancer activity. Brefeldin A 4-O-nicotinate is applicable in research related to bladder cancer.

Brefeldin-C is a useful organic compound for research related to life sciences. The catalog number is T124299 and the CAS number is 73899-78-2.

7-Dehydrobrefeldin A is a natural product that can be used as a reference standard. The CAS number of 7-Dehydrobrefeldin A is 62989-90-6.

CHNQD-01281 is a derivative of Brefeldin A and acts as an EGFR regulator. It exhibits potent antiproliferative activity against cancer cells, with IC50 values of 0.079 μM and 0.081 μM for T24 and J82 cells, respectively. CHNQD-01281 modulates both the EGFR/PI3K/AKT and EGFR/ERK pathways, influencing chemotactic effects on immune effector cells. It significantly inhibits tumor growth in T24 xenograft mouse models and extends survival in MB49 allograft mouse models by inducing cytotoxic T cell infiltration.

CHNQD-01269 is a derivative of Brefeldin A-cinnamate and acts as an Arf1 inhibitor. It demonstrates potent cytotoxic activity against HepG2 and BEL-7402 cells, with IC50 values of 0.29 μM and 0.84 μM, respectively. CHNQD-01269 is applicable in the study of hepatocellular carcinoma (HCC).