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(2)
By Target- Autophagy
- Histone Methyltransferase(2)
- Others(2)
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Results for "
bix-01294
" in TargetMol Product Catalog- Inhibitors & Agonists4
bix01294 (hydrochloride hydrate)
T355671808255-64-2
The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development. BIX01294 (hydrochloride hydrate) is a selective inhibitor of G9a HMTase (IC50 = 1.7 μM). It less effectively inhibits the HMTase G9a-like protein (GLP; IC50 = 38 μM) and has no effect on other known HMTases. BIX01294 has been used in combination with the calcium channel activator BayK8644 to facilitate the generation of induced pluripotent stem cells from somatic cells in vitro.
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BIX-01294 trihydrochloride
BIX 01294
T19591392399-03-9
BIX-01294 trihydrochloride is an inhibitor of G9a histone methyltransferase.In a cell-free assay, the IC50=2.7 μM for G9a histone methyltransferase.
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CSV0C018875
T60786442150-41-6
CSV0C018875 is a quinoline-based EHMT2 G9a inhibitor that exhibits lower cytotoxicity compared to BIX-01294 [1].
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