bisdemethoxycurcumin

Bisdemethoxycurcumin (Curcumin III) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α, 25-dihydroxy vitamin D3 to stimulate amyloid-β clearance by macrophages (optimal stimulation at 100 nM BDMC) [1]. More stable than curcumin in physiological media, BDMC suppresses proliferation of cancer cells [2]. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits LPS induction of iNOS expression [3].

(1E,6E)-Bis(demethoxy)curcumin (Curcumin III) is a natural demethoxy derivative of curcumin,with anti-inflammatory and anti-cancer activities.

Bisdemethoxycurcumin is a natural curcumin derivative that activates the AMPKα pathway to attenuate LPS-induced acute lung injury; reversibly inhibits tyrosinase and possesses anti-browning ability; enhances the antiprostate cancer efficacy of docetaxel (DTX); targets cellular pathways involved in oxidative stress and apoptosis; and is an anticancer agent.

(1E,6E)-Bis(demethoxy)curcumin (Standard) is a reference standard for research and analysis in studies involving (1E,6E)-Bis(demethoxy)curcumin. (1E,6E)-Bis(demethoxy)curcumin (Curcumin III) is a natural demethoxy derivative of curcumin,with anti-inflammatory and anti-cancer activities.

Bisdemethoxycurcumin (Standard) is the standard substance of Bisdemethoxycurcumin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Bisdemethoxycurcumin (Curcumin III) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α, 25-dihydroxy vitamin D3 to stimulate amyloid-β clearance by macrophages (optimal stimulation at 100 nM BDMC) . More stable than curcumin in physiological media, BDMC suppresses proliferation of cancer cells . It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits LPS induction of iNOS expression .

Cyclobisdemethoxycurcumin exhibits antioxidant properties, demonstrated by its half maximal inhibitory concentrations (IC50s) of approximately 250 μM in the DPPH radical scavenging assay and 15-20 μM in the 2-DR oxidation assay [1].

Octahydrocurcumin has antioxidant and and anti-inflammatory activities, it can inhibit the lipopolysaccharide (LPS)-induced inflammatory response via the mechanism of inhibiting NF-kB translocation to the nucleus. Octahydrocurcumin exhibits potent cytotoxic effect (IC50 =19.46 ug/mL) and shows high antimicrobial activity.

(3S,5S)-Octahydrocurcumin ((3S,5S)-Hexahydrobisdemethoxycurcumin) is a fungal metabolite that can be isolated from turmeric.