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bisdemethoxycurcumin

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Bisdemethoxycurcumin
Curcumin III, Didemethoxycurcumin
TL000724939-16-0
Bisdemethoxycurcumin (Curcumin III) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α, 25-dihydroxy vitamin D3 to stimulate amyloid-β clearance by macrophages (optimal stimulation at 100 nM BDMC) [1]. More stable than curcumin in physiological media, BDMC suppresses proliferation of cancer cells [2]. It down-regulates the transcriptional coactivator p300, suppressing the Wnt β-catenin pathway, and inhibits LPS induction of iNOS expression [3].
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Cyclobisdemethoxycurcumin
T826401042441-12-2
Cyclobisdemethoxycurcumin exhibits antioxidant properties, demonstrated by its half maximal inhibitory concentrations (IC50s) of approximately 250 μM in the DPPH radical scavenging assay and 15-20 μM in the 2-DR oxidation assay [1].
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(1E,6E)-Bis(demethoxy)curcumin
Curcumin III, Didemethoxycurcumin, BDMC
T6S168833171-05-0
(1E,6E)-Bis(demethoxy)curcumin (Curcumin III) is a natural demethoxy derivative of curcumin,with anti-inflammatory and anti-cancer activities.
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1,4,6-Heptatrien-3-one
BDMC, 1,4,6-Heptatrien-3-one
TN566652328-96-8
Bisdemethoxycurcumin is a natural curcumin derivative that activates the AMPKα pathway to attenuate LPS-induced acute lung injury; reversibly inhibits tyrosinase and possesses anti-browning ability; enhances the antiprostate cancer efficacy of docetaxel (DTX); targets cellular pathways involved in oxidative stress and apoptosis; and is an anticancer agent.
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