beta sitosterol

Beta-Sitosterol (SKF 14463) has recently been shown to induce G2 M arrest, endoreduplication, and apoptosis through the Bcl-2 and PI3K Akt signaling pathways. Beta-Sitosterol (SKF 14463) , a main dietary phytosterol found in plants, may have the potential for prevention and therapy for human cancer. Although the exact mechanism of action of Beta-Sitosterol (SKF 14463) is unknown, it may be related to cholesterol metabolism or anti-inflammatory effects (via interference with prostaglandin metabolism). Beta-Sitosterol (SKF 14463) induces apoptosis and activates key caspases in MDA-MB-231 human breast cancer cells.

Beta-sitosterol is one of several plant-based substances known as phytosterols.

7-Oxo-beta-sitosterol (7-Ketositosterol), a phytosterol isolated from the fruit of x giganteus, has anticancer and antitumor activity, inhibits the proliferation of HL-60 acute myeloid leukemia (AML) cells, and stimulates the growth of HL-60 acute myeloid leukemia (AML) cells through the downregulation of the levels of S1P, p-44 42 ERK1 2 and p-NF-κB p65 proteins. -κB p65 protein levels to stimulate ceramide accumulation and apoptosis, and can be used to study breast cancer.

Daucosterol (Sitogluside) has proliferation-enhancing activity, may be involved in the IGF1-AKT pathway. Daucosterol(β-Sitosterol β-D-glucoside) has efficient and inexpensive neuroprotectant effect, to contribute to IGF1-like activity, could be potentially developed as a medicine for ischemic stroke treatment.