bcn-peg4-alkyne

BCN-PEG4-alkyne is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Azido-PEG4-NHS-ester is a PEG-based linker molecule that can be used as a linker in PROTAC construction. It contains an azide group that participates in click chemistry reactions, including copper-catalyzed azide–alkyne cycloaddition (CuAAC) with alkynes, as well as strain-promoted azide–alkyne cycloaddition (SPAAC) with DBCO or BCN groups, thereby enabling molecular conjugation.

N3-PEG4-C2-NH2 is a PEG-type PROTAC linker that can be used in the synthesis of PROTAC molecules .This compound is a click chemistry reagent containing an Azide group.It can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing an Alkyne group,and can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Azido-PEG4-acyl chloride is a PROTAC linker that falls under the PEG category, utilized in the synthesis of PROTAC molecules. As a click chemistry reagent, it contains an Azide group, allowing it to undergo copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) with molecules bearing an Alkyne group. Additionally, it can partake in strain-promoted azide-alkyne cycloaddition reactions (SPAAC) with molecules containing DBCO or BCN groups.

Azido-C1-PEG4-C3-NH2 is a PROTAC linker within the PEG class, utilized in the synthesis of PROTAC molecules. Serving as a click chemistry reagent, it features an azide group capable of engaging in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) with alkyne-containing molecules. Additionally, it can undergo strain-promoted azide-alkyne cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Azido-PEG4-formylhydrazine-Boc is a PROTAC linker within the PEG category, suitable for PROTAC molecule synthesis. This compound serves as a click chemistry reagent, featuring an azide group that can participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) with alkyne-containing molecules. Additionally, it can undergo strain-promoted azide-alkyne cycloaddition reactions (SPAAC) with molecules bearing DBCO or BCN groups.

Azido-PEG4-THP is a PEG-based PROTAC linker used for synthesizing PROTAC molecules. It functions as a click chemistry reagent, featuring an Azide group capable of engaging in a copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Additionally, it can undergo a strain-promoted azide-alkyne cycloaddition (SPAAC) with molecules that have DBCO or BCN groups.

Azido-PEG4-Thiol is a PEG-based PROTAC linker used for synthesizing PROTAC molecules. As a click chemistry reagent, it possesses an azide group that can undergo copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) with molecules containing alkyne groups. Additionally, it can participate in strain-promoted azide-alkyne cycloaddition reactions (SPAAC) with molecules containing DBCO or BCN groups.

Gly-Gly-Gly-PEG4-azide is a peptide-PEG hybrid linker used in the synthesis of antibody-drug conjugates (ADCs). Gly-Gly-Gly-PEG4-azide exhibits click chemistry specificity and serves as a click chemistry reagent. Gly-Gly-Gly-PEG4-azide contains an azide group and can undergo a copper-catalyzed azide-alkyne cycloaddition (CuAAc) reaction with molecules containing an alkyne group. Gly-Gly-Gly-PEG4-azide can also undergo a ring-strain-assisted acetylene-azide cycloaddition (SPAAC) reaction with molecules containing DBCO or BCN groups.

Biotin-PEG4-SS-azide, a biotin-labeled ADC linker, is primarily utilized in the synthesis of antibody-drug conjugates (ADCs). This compound serves as a click chemistry reagent featuring an Azide group, enabling it to partake in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-bearing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Ald-Ph-PEG4-bis-PEG3-N3, a 6-unit cleavable PEG ADC linker, is used in the preparation of antibody-drug conjugates (ADCs) [1]. It serves as a click chemistry reagent featuring an Azide group, allowing it to engage in a copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with Alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules that contain DBCO or BCN groups.

Amino-PEG4-bis-PEG3-N3, a cleavable 7-unit PEG ADC linker, is used in synthesizing antibody-drug conjugates (ADCs) [1]. As a click chemistry reagent, it contains an Azide group and can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules possessing Alkyne groups. Additionally, strain-promoted alkyne-azide cycloaddition (SPAAC) can occur with molecules containing DBCO or BCN groups.

N3-PEG4-amido-Lys(Fmoc)-acid is a 4 unit PEG ADC linker utilized in the production of antibody-drug conjugates (ADCs) [1]. This compound, functioning as a click chemistry reagent, is equipped with an Azide group that enables it to partake in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with Alkyne group-bearing molecules. Additionally, it is capable of engaging in strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Fmoc-NH-Azide-PEG4-L-Lysine-PFP ester serves as a cleavable 4-unit PEG-based ADC linker in the formulation of antibody-drug conjugates (ADCs) [1]. This compound acts as a click chemistry agent featuring an Azide group, enabling it to engage in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-bearing molecules. Additionally, it facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules equipped with DBCO or BCN groups.

Azide-PEG4-Desthiobiotin is a PEG derivative composed of desthiobiotin, four PEG units, and an azide group (azide). Biotin forms a stable non-covalent complex with Streptavidin. The azide group can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. Additionally, it can participate in strain-promoted azide-alkyne cycloaddition (SPAAC) with molecules that have DBCO or BCN groups.