azido peg4 azide

Azido-PEG4-azide is a PEG-based PROTAC linker used for synthesizing PROTACs.

Azido-PEG4-CH2-Boc, a four-unit cleavable polyethylene glycol (PEG) linker compound, is used in the synthesis of antibody-drug conjugates (ADCs) [1] and PROTACs [2]. Characterized by its azide functional group and PEG backbone, it facilitates drug-antibody conjugation in ADCs and enables PROTAC synthesis using PEG and alkyl/ether moieties.

m-PEG4-azide, also referred to as 13-Azido-2,5,8,11-tetraoxatridecane, functions as a PEG-based PROTAC linker suitable for PROTACs synthesis[1].

N-(Azido-PEG3)-N-Boc-PEG4-acid is a PEG-based PROTAC linker with a terminal azide group, primarily used in PROTAC synthesis [1].

N-(Azido-PEG4)-N-Boc-PEG4-NHS ester is a PEG-based PROTAC linker with a terminal azide group, commonly used in the synthesis of PROTACs[1].

Azido-PEG3-S-PEG4-propargyl is a polyethylene glycol (PEG)-based linker containing azide and propargyl groups, designed specifically for the synthesis of proteolysis targeting chimeras (PROTACs)[1].

Azido-PEG4-acyl chloride is a PROTAC linker that falls under the PEG category, utilized in the synthesis of PROTAC molecules. As a click chemistry reagent, it contains an Azide group, allowing it to undergo copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) with molecules bearing an Alkyne group. Additionally, it can partake in strain-promoted azide-alkyne cycloaddition reactions (SPAAC) with molecules containing DBCO or BCN groups.

Azido-C1-PEG4-C3-NH2 is a PROTAC linker within the PEG class, utilized in the synthesis of PROTAC molecules. Serving as a click chemistry reagent, it features an azide group capable of engaging in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) with alkyne-containing molecules. Additionally, it can undergo strain-promoted azide-alkyne cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

Azido-PEG4-formylhydrazine-Boc is a PROTAC linker within the PEG category, suitable for PROTAC molecule synthesis. This compound serves as a click chemistry reagent, featuring an azide group that can participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) with alkyne-containing molecules. Additionally, it can undergo strain-promoted azide-alkyne cycloaddition reactions (SPAAC) with molecules bearing DBCO or BCN groups.

Azido-PEG4-THP is a PEG-based PROTAC linker used for synthesizing PROTAC molecules. It functions as a click chemistry reagent, featuring an Azide group capable of engaging in a copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Additionally, it can undergo a strain-promoted azide-alkyne cycloaddition (SPAAC) with molecules that have DBCO or BCN groups.

Azido-PEG4-Thiol is a PEG-based PROTAC linker used for synthesizing PROTAC molecules. As a click chemistry reagent, it possesses an azide group that can undergo copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) with molecules containing alkyne groups. Additionally, it can participate in strain-promoted azide-alkyne cycloaddition reactions (SPAAC) with molecules containing DBCO or BCN groups.

Azido-PEG4-acrylate is a crosslinker containing an azide group and an acrylate group. The azide group enables Click Chemistry and the acrylate group enables Michael addition. The hydrophilic PEG spacer increases solubility in aqueous media.