avermectin b1a

Avermectin B1a is a macrocyclic lactone disaccharide anthelmintic agent .

8a-OH-Avermectin B1a is a primary mono-oxidation degradation product generated during the photodegradation of Avermectin B1a. 8a-OH-Avermectin B1a is useful for research on antiparasitic infections.

Avermectin B1a aglycone is an aglycone form of the anthelmintic and insecticide avermectin B1a . It hyperpolarizes P. crassipes muscle fibers with a minimum active concentration (MAC) value of 0.1 μM. Avermectin B1a aglycone decreases survival of C. elegans (MAC = 0.1 μM). In vivo, avermectin B1a aglycone prevents seizures induced by pentylenetetrazole in mice (ED50 = 43.9 mg/kg) without inducing deficits in rotarod performance.

Avermectin B1a monosaccharide is a macrolide anthelmintic and monosaccharide form of avermectin B1a . It is lethal to C. elegans with a minimum active concentration (MAC) value of 0.1 μM. Avermectin B1a monosaccharide also stimulates conductance in isolated shore crab muscle.

Δ²-Avermectin B₁ₐ (Compound 3) is an antiparasitic agent that specifically targets glutamate-gated chloride channels (GluCls) in the neuromuscular systems of invertebrates. By increasing chloride ion influx, it causes depolarization of neuromuscular cell membranes, inhibiting neural signal transmission, which ultimately paralyzes and kills the parasite. It shows potential for research in agricultural pest control.

Avermectin B1a in Acetonitrile (Standard) is a standard material used for research and analysis of Avermectin B1a. Avermectin is a compound that inhibits the expression of Caspase-8 and Bcl-2.

4''-Oxoavermectin B1a is an enhancer targeting GABA (γ-aminobutyric acid) and glutamate-gated chloride channels, exhibiting insecticidal and acaricidal activities. It holds potential for research on agricultural pests.

Avermectin B1 is served as anthelmintic and insecticide.

2-epi-Abamectin, a degradation product of abamectin, exhibits toxicity towards the two-spotted spider mite in contact assays, possessing an LC50 value of 4 ppm. This indicates it is approximately 100-fold less potent than its precursor, abamectin.

epi-Ivermectin B1a is a significant impurity related to Ivermectin, typically found as a process-related impurity or potential degradation product in antiparasitic formulations. It is also utilized in research on both in vivo and in vitro parasites in cattle.

Eprinomectin (MK-397) is an avermectin with anthelmintic and insecticidal activities. Eprinomectin is a mixture of two chemical compounds, eprinomectin B1a and B1b.

Ivermectin B1a is the major (80%) component of commercially available ivermectin and a derivative of Avermectin B1a.

Eprinomectin B1a, composing over 90% of the antiparasitic agent eprinomectin, is a primary component alongside eprinomectin B1b, which constitutes less than 10%. This compound is part of the avermectin family, used as insecticides and anthelmintics.

Ivermectin B1a-d2-1 is the deuterium-labeled form of Ivermectin B1a. As a derivative of Avermectin B1a, Ivermectin B1a constitutes the primary component of Ivermectin. Ivermectin (MK-933) is a broad-spectrum antiparasitic agent and is also being considered as a candidate active molecule in the treatment of SARS-CoV-2/COVID-19.

8,9-Z-Abamectin B1a is the 8,9-Z-isomer of Abamectin B1a. Avermectin B1a serves as an anthelmintic agent, capable of paralyzing nematodes.