avermectin

Avermectin is a useful organic compound for research related to life sciences and the catalog number is T64965.

Emamectin Benzoate (MK-244), by binding gamma-aminobutyric acid (GABA) receptor and glutamate-gated chloride channels disrupting nerve signals within arthropods, acts as a chloride channel activator.

Ivermectin B1a is the major (80%) component of commercially available ivermectin and a derivative of Avermectin B1a.

Δ²-Avermectin B₁ₐ (Compound 3) is an antiparasitic agent that specifically targets glutamate-gated chloride channels (GluCls) in the neuromuscular systems of invertebrates. By increasing chloride ion influx, it causes depolarization of neuromuscular cell membranes, inhibiting neural signal transmission, which ultimately paralyzes and kills the parasite. It shows potential for research in agricultural pest control.

8a-OH-Avermectin B1a is a primary mono-oxidation degradation product generated during the photodegradation of Avermectin B1a. 8a-OH-Avermectin B1a is useful for research on antiparasitic infections.

Avermectin B2a is an insecticide that targets glutamate-gated chloride channels (GluCls). It causes hyperpolarization in nematode or insect neurons, leading to paralysis or death. Avermectin B2a shows potential for research on agricultural pests.

Avermectin A1a is a potent and broad-spectrum antiparasitic agent. It functions by binding to glutamate-gated chloride channels in nematodes and arthropods, thereby blocking neural signal transmission and inducing paralysis. Avermectin A1a is applicable for research on parasitic infections.

Avermectin B1 is served as anthelmintic and insecticide.

Avermectin B1a aglycone is an aglycone form of the anthelmintic and insecticide avermectin B1a . It hyperpolarizes P. crassipes muscle fibers with a minimum active concentration (MAC) value of 0.1 μM. Avermectin B1a aglycone decreases survival of C. elegans (MAC = 0.1 μM). In vivo, avermectin B1a aglycone prevents seizures induced by pentylenetetrazole in mice (ED50 = 43.9 mg/kg) without inducing deficits in rotarod performance.

Avermectin B1a monosaccharide is a macrolide anthelmintic and monosaccharide form of avermectin B1a . It is lethal to C. elegans with a minimum active concentration (MAC) value of 0.1 μM. Avermectin B1a monosaccharide also stimulates conductance in isolated shore crab muscle.

Avermectin B1a is a macrocyclic lactone disaccharide anthelmintic agent .

Avermectin B1a in Acetonitrile (Standard) is a standard material used for research and analysis of Avermectin B1a. Avermectin is a compound that inhibits the expression of Caspase-8 and Bcl-2.

2-epi-Abamectin, a degradation product of abamectin, exhibits toxicity towards the two-spotted spider mite in contact assays, possessing an LC50 value of 4 ppm. This indicates it is approximately 100-fold less potent than its precursor, abamectin.

epi-Ivermectin B1a is a significant impurity related to Ivermectin, typically found as a process-related impurity or potential degradation product in antiparasitic formulations. It is also utilized in research on both in vivo and in vitro parasites in cattle.

4''-Oxoavermectin B1a is an enhancer targeting GABA (γ-aminobutyric acid) and glutamate-gated chloride channels, exhibiting insecticidal and acaricidal activities. It holds potential for research on agricultural pests.

Doramectin (Dectomax) is an antiparasitic agent.

Eprinomectin (MK-397) is an avermectin with anthelmintic and insecticidal activities. Eprinomectin is a mixture of two chemical compounds, eprinomectin B1a and B1b.

Eprinomectin B1b, a minor component of the avermectin family, is used as an insecticide and anthelmintic.

Eprinomectin B1a, composing over 90% of the antiparasitic agent eprinomectin, is a primary component alongside eprinomectin B1b, which constitutes less than 10%. This compound is part of the avermectin family, used as insecticides and anthelmintics.

Ivermectin B1a-d2-1 is the deuterium-labeled form of Ivermectin B1a. As a derivative of Avermectin B1a, Ivermectin B1a constitutes the primary component of Ivermectin. Ivermectin (MK-933) is a broad-spectrum antiparasitic agent and is also being considered as a candidate active molecule in the treatment of SARS-CoV-2/COVID-19.

Eprinomectin (Standard) is the standard substance of Eprinomectin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Eprinomectin (MK-397) is an avermectin with anthelmintic and insecticidal activities.

8,9-Z-Abamectin B1a is the 8,9-Z-isomer of Abamectin B1a. Avermectin B1a serves as an anthelmintic agent, capable of paralyzing nematodes.