av153

AV-153 is a 1,4-dihydropyridine derivative with antimutagenic properties. It intercalates into DNA at single strand breaks, resulting in reduced DNA damage and stimulation of DNA repair in human cells in vitro. AV-153 also interacts with thymine and cytosine and influences poly(ADP)ribosylation. Moreover, AV-153 exhibits anti-cancer activity.

AV-153 free base is a 1,4-dihydropyridine (1,4-DHP) derivative with antimutagenic and anti-cancer activity. It interacts with cytosine and thymine, influences poly(ADP)ribosylation, intercalates to DNA at single-strand breaks, reduces DNA damage, and stimulates DNA repair in human cells in vitro [1] [2] [3].