astragaloside

Astragaloside, one of the main active ingredients in Astragalus membranaceus.

Astragaloside IV (AS-IV), an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1 2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells. Astragaloside IV is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine.1 It dose-dependently inhibits human adenovirus type 3 (HAdV-3) in A549 cells (IC50 = 23 μM; LC50 = 865 μM).It inhibits replication of HAdV-3 and decreases HAdV-3-induced apoptosis. It has diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. In particular, it reduces myocardial infarct size in dogs when administered prior to coronary ligation and reduces reperfusion arrhythmias in isolated rat hearts.

Astragaloside A (Astramembrannin I) is the primary pure saponin isolated from Astragalus membranaceus.

Astragaloside VI could improve wound healing by activating the EGFR ERK signaling pathway.

Astragaloside II (Astrasieversianin VIII) is an effective MDR reversal agent and may be a potential adjunctive agent for hepatic cancer chemotherapy. Astragaloside II also induces osteogenic activities, differentiation, proliferation, and mineralization, through the bone morphogenetic protein-2 MAPK and Smad1 5 8 pathways.

Astragaloside I (Cyclosieversioside B) is a natural product isolated from Astragalus membranaceus. It can stimulate osteoblast differentiation through the Wnt β-catenin signaling pathway and can be used to study osteogenic activity.

Astragaloside III has cardioprotective effects as well as causing improvement in cognitive function. It can be used in the prevention of cardio-cerebral vascular diseases. It also is antioxidant.

Isoastragaloside II (Astrasieversianin VII) is a derivative Astragaloside I, an ingredient in Astragalus membranaceus which is reported to have osteogenic properties.

Agroastragaloside I is a type of astragaloside that can be isolated from hairy root cultures of Astragalus.

Isoastragaloside IV is a natural product

Neoastragaloside I is a natural product

Acetytastragaloside is a natural product.

Isoastragaloside I is a natural product,has the enhancement adiponectin quantity activity.