api2

Triciribine (NSC-154020) is a DNA synthesis inhibitor, and it also inhibits Akt and HIV-1 2.

NaPi2b is primarily expressed in the small intestine, lungs, and testes and plays an important role in phosphate homeostasis. The inhibition of NaPi2b, responsible for intestinal phosphate absorption, is considered to reduce serum phosphate levels, making it a promising therapeutic approach for hyperphosphatemia

NaPi2b-IN-2 (compound 5) is a potent inhibitor of the sodium-dependent transport protein 2b (SLC34A2, NaPi2b), with an IC50 of 38 nM against human NaPi2b. It holds potential for hyperphosphatemia research [1].