antipyretic compound

Benoxaprofen (NSC-299582) is a non-steroidal anti-inflammatory drug.

Butibufen (FF-106) is an orally active non-steroidal anti-inflammatory compound, a potential cyclooxygenase inhibitor with analgesic and antipyretic activity, and inhibits urea synthesis.Butibufen has been used in the study of rheumatic diseases.

Isoxepac (Olopatadine USP Related Compound C) is a non-steroidal anti-antiphlogistic agent and analgesic.

Etoricoxib-D4 is a deuterated form of Etoricoxib. Etoricoxib (T1574) is a synthetic non-steroidal anti-inflammatory compound, an orally available and selective COX-2 inhibitor with antipyretic, analgesic, and potential anticancer properties.

Detanosal is a compound that possesses antipyretic (fever-reducing), analgesic (pain-relieving), and anti-inflammatory effects.

AGU654 (Compound 44) is a selective mPGES-1 inhibitor with an IC50 value of 2.9 nM against mPGES-1. By inhibiting mPGES-1, AGU654 interrupts the pathway where COX-1/2 converts arachidonic acid to prostaglandin E2 (PGE2), effectively reducing inflammatory responses, pain, and fever symptoms. In models using activated human monocyte-derived macrophages and whole blood, AGU654 selectively inhibits PGE2 production induced by bacterial endotoxins, while preserving the production of other prostaglandins. In guinea pig models, AGU654 significantly alleviates fever, inflammation, and inflammatory pain, demonstrating excellent anti-inflammatory, analgesic, and antipyretic effects. AGU654 holds promise as a new approach for researching inflammatory diseases and pain.

COX-1-IN-5 (example 13, compound PS13) is a potent and selective COX-1 inhibitor with an IC50 of 1 nM, significantly more selective for COX-1 over COX-2 (COX-2 IC50 > 0.1 μM) by over 1000-fold. It demonstrates substantial anti-inflammatory, antipyretic, analgesic, antithrombotic, and anticancer activities. COX-1-IN-5 is applicable in the study of COX-mediated diseases such as inflammation and pain. When radiolabeled with 11C, it serves as a selective PET tracer for systemic imaging of COX-1 distribution and target binding in vivo.

Oxametacin is a anti-inflammatory compound with analgesic, antipyretic and anti-inflammatory properties.

Acetaminophen Glucuronide sodium salt (APAP-glu) is a compound with antipyretic and analgesic activity and is an acetaminophen metabolite with potential nephrotoxicity.

Falimint is a compound with antipyretic and analgesic activity [1].

Isofezolac (LM 22070) is a non-steroidal anti-inflammatory drug (NSAID) known for its potent inhibition of prostaglandin-synthetase, exhibiting significant anti-inflammatory and antipyretic properties [1] [2].

Antipyrine-D3 is a deuterated compound of Antipyrine. Antipyrine (T0734) has a CAS number of 60-80-0. Antipyrine, an antipyretic and analgesic, has been given as ear drops and by mouth. Antipyrine (T0734) is frequently used to test the effects of other diseases or drugs on drug-metabolizing enzymes in the liver.

MAA-D3 is a deuterated compound of MAA. MAA has a CAS number of 519-98-2. 4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. 4-Methylamino antipyrine has analgesic, antipyretic, and relatively weak anti-inflammatory properties.

MefenaMic Acid-D4 is a deuterated compound of MefenaMic Acid. MefenaMic Acid (T0890) has a CAS number of 61-68-7. Mefenamic acid is a non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.

Flunixin-D3 (methyl-D3) is a deuterated compound of Flunixin. Flunixin (T20869) has a CAS number of 38677-85-9. Flunixin (T20869) is a nonsteroidal anti-inflammatory drug (NSAID), antipyretic, and analgesic used in pigs, horses, and cattle.

Ibuprofen-D2 is a deuterated compound of Ibuprofen. Ibuprofen (T1394) has a CAS number of 15687-27-1. Ibuprofen (T1394) is a propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen (T1394) inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes.

Carprofen (Standard) is a reference substance for quantitative analysis and quality control in biochemical experiments. Carprofen (Ridamyl) is a propionic acid derivative nonsteroidal anti-inflammatory compound with anti-inflammatory, analgesic, and antipyretic activities, and Carprofen (Standard) is utilized in analytical chemistry research focused on assay calibration, pharmacokinetic quantification, and quality control methodologies.

Cinnamaldehyde (Standard) is the reference compound for quantitative analysis, quality control, and biochemical research. Cinnamaldehyde exhibits antipyretic and sedative activities, inhibits the invasive potential of MDA-MB-435S cancer cells through downregulation of miR-27a, induces reactive oxygen species, exerts vasodilatory and anticancer effects, and has potential as an adjuvant in combination therapy with chemotherapeutics such as 5-fluorouracil and oxaliplatin, while also inhibiting melanoma progression via suppression of VEGF and HIF-a-mediated angiogenesis.