angiotensin ii acetate

Angiotensin II human acetate is a key vasoconstrictor peptide in the renin-angiotensin system. It regulates blood pressure by binding to AT1R and AT2R receptors, stimulates the sympathetic nervous system, promotes aldosterone synthesis and renal function, induces vascular smooth muscle cell proliferation and collagen synthesis, leading to vascular and myocardial hypertrophy and fibrosis, while also promoting apoptosis and endothelial capillary formation. It is commonly used to induce hypertension and cardiac hypertrophy models.

(Sar¹)-Angiotensin II acetate, an analogue of Angiotensin II, is a specific agonist of angiotensin AT1 receptor. It binds to brain membrane-rich particles, with a Kd of 2.7 nM. It can stimulate protein synthesis and cell growth in embryonic chick myocytes.

[Sar1, Ile8]-Angiotensin II acetate activates both the NADPH and NADH oxidases, and stimulates superoxide anion formation in vascular smooth muscle cells. [Sar1, Ile8]-Angiotensin II acetate has multiple effects on vascular smooth muscle, including contra

Saralasin acetate is a Non-selective angiotensin II antagonist.

Angiotensin II 5-valine acts as an agonist at the angiotensin receptor.

Angiotensin (1-7) acetate (Ang-(1-7) acetate) is an amino acid sequence present in angiotensin, which has antifibrotic and cardioprotective effects and inhibits the activity of purified canine angiotensin converting enzyme (ACE). Angiotensin (1-7) acetate inhibits the growth of tumor cells and reduces local inflammation and angiogenesis in several types of cancer, blocks angiotensin II-induced smooth muscle cell proliferation and hypertrophy, and can be used to study atherosclerosis and novel coronavirus infection.

TRV055 acetate is a ligand of angiotensin II type 1 receptor and stimulates cellular Gq-mediated signaling.

TRV-120027 acetate is a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1 receptor) and engages -arrestins while blocking G-protein signaling.