amine-peg-ch2cooh

Amine-PEG-CH2COOH (MW 2000) is a polyethylene glycol (PEG) derivative used as a linker in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

Amine-PEG-CH2COOH (MW 3400) is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis targeting chimeras (PROTACs).

Amine-PEG-CH2COOH (MW 5000) is a PEG-based PROTAC linker that can be used in PROTAC synthesis.

t-Butyl ester-PEG4-CH2COOH is a PEG linker characterized by the presence of a tert-butyl group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of an activator (e.g., HATU) to form a stable amide bond. The hydrophilic PEG spacer improves solubility in aqueous media. The tert-butyl group can be deprotected under acidic conditions.

CbzNH-PEG4-CH2COOH is a PEG linker featuring a carboxylic acid (CO2H) group and a benzyloxycarbonyl (Cbz) protecting group. The hydrophilic PEG spacer enhances the compound's solubility in aqueous media. In the presence of activators such as HATU, the terminal carboxylic acid can react with primary amine groups to form stable amide bonds. The benzyloxycarbonyl protecting group can be removed through hydrogenolysis to yield a free amine.