ahp

Bicuculline is an alkaloid extracted from Corydalis decumbens, acting as a competitive antagonist of the neurotransmitter GABAA receptor (IC50 = 2 μM). It also blocks Ca2+-activated potassium (SK) channels and inhibits slow afterhyperpolarization (slow AHP). Bicuculline has anticonvulsant effects and is commonly used to establish mouse seizure models.

(-)-Bicuculline methochloride is a potent antagonist of GABAA receptor.

Bicuculline methochloride is a competitive GABAA receptor antagonist and allosteric inhibitor with an IC50 of 1.7 μM. It blocks Ca²⁺-dependent activation of potassium channels, exhibits convulsant activity, and is suitable for epilepsy research.

Bicuculline methobromide is a selective GABAA receptor antagonist with an IC50 of 3 μM. It can induce clonic-tonic seizures in mammals and block Ca²⁺-activated potassium channels, commonly used to establish models of epilepsy and related neurological disorders.