actinomycete

Erythromycin (E-Mycin) is a Macrolide and Macrolide Antimicrobial. The physiologic effect of erythromycin is by means of Decreased Sebaceous Gland Activity.

Toyocamycin (Vengicide) is an adenosine analog produced by Actinomycetes, functioning as an XBP1 inhibitor and inhibiting IRE1α-induced ATP-dependent XBP1 mRNA cleavage (IC50: 80 nM), and induces apoptosis.

5'-Fluoro-5'-deoxyadenosine (5'-Fluoro-5'-deoxy-adenosine) is utilized commonly as a tool for studying the Actinomycete bacterium Streptomyces cattleya.

Oxytetracycline (Terramycin) is a TETRACYCLINE analog isolated from the actinomycete STREPTOMYCES rimosus and used in a wide variety of clinical conditions.

Erythromycin thiocyanate is a macrolide antibiotic produced by actinomycetes with a broad antibacterial spectrum. It inhibits RNA-dependent protein synthesis by binding to the bacterial 50S ribosomal subunit and blocking transpeptidation and translocation, without interfering with nucleic acid synthesis. It has also shown antitumor and neuroprotective activities in multiple studies.

Fervenulin is isolated from a nematicidal actinomycete Streptomyces sp. CMU-MH021 with nematicidal activity. It also inhibits egg hatch and J2 mortality of M. incognita (MICs: 30 μg/mL and 120 μg/mL, respectively).

K-252b, an indolocarbazole derived from the actinomycete Nocardiopsis, functions as a protein kinase C (PKC) inhibitor. It is effective in inhibiting extracellular kinases in cultured cells due to its inability to freely cross the cell membrane.

Tuberactinomycin compounds are essential components in the current combination of drugs used to combat Mycobacterium tuberculosis infections. These compounds target bacterial ribosomes and function by binding RNA and disrupting bacterial protein biosynthesis. Tuberactinomycin is produced by the actinomycete [Streptomyces puniceus], which binds RNA and inhibits protein synthesis in prokaryotes as well as certain forms of RNA splicing.

Lincomycin-B is a lincosamide antibiotic isolated from the actinomycete Streptomyces lincolnensis.

Propioxatin A is an enkephalinase B inhibitor isolated from actinomycete.

Propioxatin B is an enkephalinase B inhibitor isolated from actinomycete.

A 83016F, an antibiotic from an actinomycete designated A83016, exhibits weak antimicrobial activity.

Luminamicin is active against anaerobic bacteria, especially Clostridium sp.; isolated from actinomycete strain OMR-59.

Lydicamycin is a new antibiotic isolated from the fermentation broth of an actinomycete strain identified as Streptomyces solani. Lydicamycin is active against Gram-positive bacteria and certain yeasts, but inactive against Gram-negative bacteria. [2]

N-Methylstreptothricin F is a streptothrycin isolated from actinomycete.

Salinosporamide B is a deschloro analog isolated from the marine Actinomycete Salinispora tropica.

Salinosporamide C is a decarboxylated pyrrole analogue isolated from the marine Actinomycete Salinispora tropica.

Simaomicin alpha is an actinomycete metabolite isolated from an actinomycete strain.

Drimentine A, a terpenylated diketopiperazine antibiotic originally isolated from Actinomycete bacteria, exhibits activity against Gram-positive and Gram-negative bacteria, fungi, and yeast, and possesses anthelmintic properties.

Drimentine B is a terpenylated diketopiperazine antibiotic originally isolated from Actinomycete bacteria. It is active against Gram-positive and Gram-negative bacteria, fungi, and yeast, and possesses anthelmintic properties. Drimentine B inhibits the proliferation of NS-1 murine β lymphocyte myeloma cells by 41% and 59% in vitro at concentrations of 50 μg/ml and 100 μg/ml, respectively.

IKD-8344 is a macrocyclic dilactone originally isolated from an actinomycete species with diverse biological activities, including anticancer, antimicrobial, and anthelmintic properties [1,2,3]. It is cytotoxic to L5178Y murine leukemia cells (IC50 = 0.54 ng/ml) [1], inhibits growth of the mycelial form of C. albicans (MIC = 6.25 μg/ml), and potentiates the activity of polymyxin B against the multidrug-resistant pathogenic bacterium B. cenocepacia [2,3]. Additionally, it is active against T. spiralis in vitro and in vivo [1].

Kibdelone C is a member of a family of natural heterocyclic polyketides first isolated from a soil actinomycete, Kibdelosporangium. Kibdelones have been described as having potent and selective cytotoxicity against a panel of human tumor cell lines, and kibdelone C has low nanomolar effectiveness in these assays. Kibdelone C disrupts the actin cytoskeleton without directly binding actin or affecting its polymerization in vitro.

Resistoflavine, a metabolite of the marine actinomycete S. chibaensis, inhibits growth and exhibits cytotoxicity against HMO2 and HepG2 cells, with mean lethal concentrations (LC50) of 0.013 and 0.016 μg/ml, respectively.

Saccharocarcin B was isolated from the fermentation broth of the actinomycete Saccharothrix aerocolongenes subsp.antibiotica SCC1886.