ac 100

Dentonin (AC-100) is a synthetic fragment derived from MEPE that enhances osteogenesis by promoting osteoprogenitor adhesion and facilitating the survival of immature adherent cells, without significantly affecting mature osteoblasts. Dentonin is valuable for research on phosphate homeostasis and bone metabolism.

Fz7-21 ((Ac)-LPSDDLEFWCHVMY-NH2) is a peptide antagonist of FZD7 . It antagonises WNT3A-induced Wnt-β-catenin signalling in HEK293 expressing FZD7. Fz7-21 impairs Wnt/β-catenin signaling in HEK293 cells stimulated with exogenous WNT3A (IC50=100 nM) or transfected with a construct expressing WNT3A or WNT1. Fz7-21 also blocks WNT3A-mediated stabilization of β-catenin in mouse L cells (IC50=50 nM).