T7224

Anabasine ((S)-Anabasine) is an alkaloid extracted from tobacco, acting as a full agonist of nicotinic acetylcholine receptors (nAChRs) with insecticidal activity. It depolarizes TE671 cells that endogenously express human myotypic nAChRs.

Romifidine hydrochloride, an α2 adrenergic receptor agonist, induces sedation effects in vivo.

Teslexivir hydrochloride (BTA074) is a potent antiviral agent and selective inhibitor of the E1 and E2 viral proteins' interaction, essential for DNA replication and viral production in Human Papilloma Virus (HPV) types 6 and 11. This compound is used in research on condyloma.

DYRKs-IN-1 hydrochloride is a potent inhibitor of Dual-specificity tyrosine-phosphorylation-regulated kinases (DYRKs), with IC50 values of 5 nM for DYRK1A and 8 nM for DYRK1B, and exhibits antitumor activity.

Cyclic di-GMP (c-di-GMP) diammonium is a STING activator and a global bacterial second messenger, which regulates biofilm formation, motility, and virulence in diverse bacterial species .

Fomepizole hydrochloride (4-Methylpyrazole), a potent, orally active inhibitor of cytochrome P450 (CYP2E1) and a competitive inhibitor of alcohol dehydrogenase, prevents the conversion of methanol and ethylene glycol into toxic metabolites. It has potential as an antidote for poisoning by ethylene glycol or methanol.

Bicuculline methobromide is a selective GABAA receptor antagonist with an IC50 of 3 μM. It can induce clonic-tonic seizures in mammals and block Ca²⁺-activated potassium channels, commonly used to establish models of epilepsy and related neurological disorders.

Ladostigil hydrochloride (TV-3326), an orally active compound, acts as a dual inhibitor targeting both cholinesterase and brain-selective monoamine oxidase (MAO), demonstrating inhibition constants (IC50s) of 31.8 μM for acetylcholinesterase (AChE) and 37.1 μM for MAO-B. This compound exhibits neuroprotective, antioxidant, and anti-inflammatory properties, making it useful for research into depression and Alzheimer's disease.

MRS2768 tetrasodium salt, a moderately potent and selective agonist of the P2Y2 receptor, exhibits a protective effect against ischemic damage in cardiomyocytes both in vivo and in vitro.

BMS-823778 hydrochloride is a potent, selective, and orally active inhibitor of 11β-HSD1 (11β-Hydroxysteroid Dehydrogenase Type 1), with an IC50 (half maximal inhibitory concentration) of 2.3 nM against the human enzyme.