ripk1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12730	RIPK1-IN-4		RIP kinase
	RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase).		RIP kinase
T12731	RIPK1-IN-7		RIP kinase
	RIPK1-IN-7 is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic IC50 of 11 nM),andexhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model.		RIP kinase
T63055	RIPK1-IN-9		RIP kinase
	RIPK1-IN-9 is a potent and selective inhibitor of RIPK1, a dihydronaphthone compound, which inhibits U937 and L929 cells with an IC50 of 2 nM and 1.3 nM, respectively.		RIP kinase
T12729	RIPK1-IN-3		Others
	RIPK1-IN-3 is a RIPK1 inhibitor, with anti-inflammatory proprieties.		Others
T81268	RIPK1-IN-17		RIP kinase
	RIPK1/3-IN-1 (Compound 10) is a selective inhibitor of both RIPK1 and RIPK3, effectively preventing necroptosis by blocking the phosphorylation of RIPK1, RIPK3, and MLKL [1].		RIP kinase
T64064	RIPK1-IN-10
	RIPK1-IN-10 is a potent inhibitor of RIPK1.
T61887	RIPK1-IN-13
	RIPK1-IN-13 (Compound 8) is an effective RIPK1 inhibitor (IC50=1139 nM). By inhibiting RIPK1, RIPK1-IN-13 can block the activation of necrotic apoptosis pathway. RIPK1-IN-13 has research potential in inflammatory disease...
T63469	RIPK1-IN-8
	RIPK1-IN-8 is an aminoimidazolopyridine and is a selective and potent inhibitor of RIPK1 (IC50: 4 nM).RIPK1-IN-8 has research potential in inflammatory diseases.
T81269	RIPK1-IN-16		RIP kinase
	RIPK1-IN-16 is an orally active, potent RIPK1 inhibitor that mitigates excessive inflammation via inhibition of RIPK1-mediated necroptosis in vivo. It shields mice from TNF-induced systemic inflammatory response syndrome...		RIP kinase
T62499	RIPK1-IN-14
	RIPK1-IN-14 (Compound 41) is a potent inhibitor of RIPK1 (IC50: 92 nM).RIPK1-IN-14 has a significant anti-necrotic apoptotic effect in a model of necrotic apoptosis in U937 cells.
T62762	RIPK1-IN-11
	RIPK1-IN-11 is an orally active RIPK1 inhibitor with a Kd value of 9.2 nM and an IC50 value of 67 nM. RIPK1-IN-11 inhibits necrosis in human and mouse cells and exhibits anti-inflammatory effects.
T62723	RIPK1-IN-12
	RIPK1-IN-12 is a potent inhibitor of RIPK1, which exhibits an inhibitory effect on necroptosis in human and mouse cells with EC50 values of 1.6 and 2.9 nM, respectively.
T60862	RIPK1-IN-15
	RIPK1-IN-15 (Compound 2.5) is a potent RIPK1 inhibitor that has the potential in neurodegenerative, autoimmune, and inflammatory diseases research [1].
T12493	PK68		Others , RIP kinase
	PK68 is an effective and selective inhibitor of type II receptor-interacting kinase 1 (RIPK1, IC50 = 90 nM). PK68 can be used for research on the treatment of inflammatory disorders and cancer metastasis.		Others , RIP kinase
T9095	Necrostatin-34	2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4	RIP kinase
	Necrostatin-34 (2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4) is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain.		RIP kinase
T9079	Apostatin-1	Apt-1	Others
	Apostatin-1 (Apt-1) is a novel TRADD inhibitor. Apostatin-1 can bind to a pocket on the N-terminal TRAF2 binding domain of TRADD.		Others
T7504	Necrostatin 2 racemate	Necrostatin-2 racemate	RIP kinase
	Necrostatin 2 racemate (Necrostatin-2 racemate) is an potent and specific inhibitor of RIPK1.		RIP kinase
T8931L	ICCB-19 hydrochloride	ICCB-19 HCl（750621-52-4 free base）	Apoptosis , Others , Autophagy , RIP kinase
	ICCB-19 hydrochloride (ICCB-19 HCl) is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the N-terminal TRAF2-binding domain of TRADD (TRADD-N), which interacts with the C-terminal dom...		Apoptosis , Others , Autophagy , RIP kinase
T9702	Eclitasertib		RIP kinase
	Eclitasertib is a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1, IC50 of <1 µΜ).		RIP kinase
T9305	Necroptosis-IN-1		RIP kinase
	Necroptosis-IN-1 is a potent necroptosis inhibitor of RIPK1. It is an analog of Necrostatin-1.		RIP kinase