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PP2A

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    41
    TargetMol | Inhibitors_Agonists
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    3
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    8
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DT-061
T10060L1809427-19-7In house
DT-061, an orally bioavailable protein phosphatase 2A (PP2A) activator, may be used in the therapy of KRAS-mutant and MYC-driven tumorigenesis.
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8-10 weeks
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Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride
T650862746-19-2
Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride may cause sensitization. Cis-5-Norbornene-exo-2,3-dicarboxylic Anhydride promotes apoptosis in HepG2 (IC50= 62 μM) and SK-Hep1 (IC50= 151 μM) cells and inhibits protein phosphatase 2A.
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7-10 days
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TargetMol | Inhibitor Sale
D-ERYTHRO-SPHINGOSINE
trans-4-Sphingenine, Sphingosine-1-phosphate, Sphingosine (d18:1), Sphinganine, Erythrosphingosine, erythro-C18-Sphingosine
T5891123-78-4
D-erythro-Sphingosine (trans-4-Sphingenine) is a protein kinase C (PKC) inhibitor. D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator
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Okadaic acid
T1638178111-17-8
Okadaic acid is a potent polyether marine toxin that accumulates in the digestive glands of marine mollusks.Okadaic acid is a highly potent and selective protein phosphatase (PP) inhibitor, inhibiting PP1, PP2A, PP3, PP4, and PP5.Okadaic acid activates Wnt β-catenin signaling in human HepaRG cells. catenin signaling in human HepaRG cells.
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Microcystin-LR
Toxin T 17 (Microcystis aeruginosa), Microcystin-LR, Microcystis aeruginosa, MC-LR, Cyanoginosin-LR
T5204101043-37-2
Microcystin-LR (Cyanoginosin-LR) is a potent inhibitor of type 1 and type 2A protein phosphatases (PP1 and PP2A), with IC50s of 1.7 nM and 0.04 nM, respectively.
    Inquiry
    PP2A Cancerous-IN-1
    T632591403933-79-8
    PP2A Cancerous-IN-1 is a potent inhibitor of CIP2A (Cancerous inhibitor of PP2A) and p-Akt, demonstrating significant anti-proliferative effects.
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    6-8 weeks
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    TPP2a bromide
    T701311838592-80-5
    TPP2a is a mitochondrial thioredoxin reductase (TrxR) inhibitor.
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    6-8 weeks
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    Endothall
    T2747145-73-3In house
    Endothall is a protein phosphatase 2A (PP2A) inhibitor, capable of inhibiting PP2A (IC50: 90 nM) and PP1 (IC50: 5 uM). It acts as a herbicide and can also be useful in cancer chemotherapy.
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    4-6 weeks
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    MKI-1
    MASTL Kinase Inhibitor-1
    T606881190277-80-5In house
    MKI-1 (MASTL Kinase Inhibitor-1) is an inhibitor of MASTL (microtubule-associated serine threonine kinase-like, IC50= 9.9 μM). MKI-1 exerts radiosensitizer and antitumor activities through PP2A activation in breast cancer.
    • Inquiry Price
    6-8 weeks
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    Calyculin A
    (-)-Calyculin A
    T14859101932-71-2
    Calyculin A ((-)-Calyculin A), a toxicant in the Japanese marine sponge CDiscodermia calyxC, is a selective and potent inhibitor of protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A), inducing hyperactivation of cryopreserved bovine spermatozoa and inhibiting radiation-induced gammaH2AX DNA repair disease in human lymphocytes. gammaH2AX DNA repair foci in human lymphocytes.
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    (Rac)-LB-100
    T20682061038-65-9
    (Rac)-LB-100, a novel Protein Phosphatase 2A (PP2A) inhibitor, sensitizes malignant meningioma cells to the therapeutic effects of radiation
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    LB100
    LB-100, LB 100
    T44491632032-53-1
    LB100 (LB-100) is a water soluble protein phosphatase 2A (PP2A) inhibitor.
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    TargetMol | Inhibitor Sale
    Ethoxysanguinarine
    6-Ethoxydihydrosanguinarine
    TN130528342-31-6
    Ethoxysanguinarine (6-Ethoxydihydrosanguinarine) shows human blood acetylcholinesterase (HuAChE) and human plasma butyrylcholinesterase (HuBuChE) inhibitory activity, with IC50 values of 0.83 + - 0.04 microM and 4.20 + - 0.19 microM, respectively.
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    IQ 1
    IQ1, IQ-1
    T3635331001-62-8
    IQ 1 has multiple roles, such as maintaining the multifunctionality of mouse ESCs, decreasing Wnt-stimulated phosphorylation, blocking PP2A Nkd interactions, and so on.
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    MP07-66
    T97441938056-90-6
    MP07-66 is a novel FTY720-analog devoid of immunosuppressive effects leads to the reactivation of PP2A, which in turn triggers apoptosis of CLL cells.
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    (1S,2S,3R)-DT-061
    T100601809427-20-0
    (1S,2S,3R)-DT-061, an enantiomer of DT-061, is an orally bioavailable activator of PP2A.
    • Inquiry Price
    6-8 weeks
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    SMAP-2
    DT-1154
    T129341809068-70-9
    SMAP-2 is an orally bioavailable activator of phosphatase 2A (PP2A) which binds to the PP2A Aα scaffold subunit to drive conformational changes in PP2A. It inhibits the growth of KRAS-mutant lung cancers .
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    6-8 weeks
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    Tautomycin
    T13095109946-35-2
    Tautomycin is a potent and specific protein phosphatases 1 and 2A inhibitor (Kiapp of 0.16 nM and 0.4 nM for PP1 and PP2A, respectively), and is an antifungal antibiotic isolated from the bacterium Streptomyces verticillatus.
    • Inquiry Price
    3-6 months
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    ATUX-8385
    T2041962088956-86-7
    ATUX-8385 is a potent activator of PP2A. It binds to the PR65 subunit and holds promise for research into cancer and chronic diseases, including Alzheimer's disease and chronic obstructive pulmonary disease (COPD).
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    10-14 weeks
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    1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine
    16:1 PE, 1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine
    T20528561599-23-3
    1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine (16:1 PE) is a phosphatidylethanolamine that can enhance the activities of PP2A and PTP1B in malignant pleural mesothelioma cells. Additionally, 1,2-Dipalmitoleoyl-sn-glycero-3-phosphoethanolamine induces apoptosis in NCI-H28 malignant pleural mesothelioma cells.
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    Rubratoxin A
    T2616422467-31-8
    Rubratoxin A is a classical mycotoxin used as a PP2A-specific inhibitor.
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    FTY720-Mitoxy
    FTY 720 Mitoxy,FTY-720-Mitoxy
    T318821604816-11-6
    FTY720-Mitoxy is an FTY720 analog that can be uesd as a novel stimulator of the activity of the protein phosphatase 2A (PP2A), targeting mitochondria.
      6-8 weeks
      Inquiry
      TD52
      T355281798328-24-1
      TD52 is an orally active inhibitor of cancerous inhibitor of PP2A (CIP2A). TD52 is an Erlotinib derivative and indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter.
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      1-2 weeks
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      TD52 dihydrochloride
      TD52 dihydrochloride(1798328-24-1 Free base), TD52 2HCl
      T35528L
      TD52 dihydrochloride (TD52 2HCl), a derivative of Erlotinib, is a potent and orally active inhibitor of protein phosphatase 2A (CIP2A). It exhibits strong anti-cancer properties by regulating the CIP2A PP2A p-Akt signaling pathway, resulting in the induction of apoptosis in triple-negative breast cancer (TNBC) cells. Mechanistically, TD52 dihydrochloride disrupts the binding of Elk1 to the CIP2A promoter, effectively reducing CIP2A levels. Notably, TD52 dihydrochloride demonstrates powerful anti-cancer activity while displaying less inhibition of p-EGFR.
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