pp2a — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2747	Endothall		Others
	Endothall is an effective protein phosphatase 2A (PP2A) inhibitor, exerting inhibitory effects on both PP2A and PP1, with IC50 values of 90 nM and 5 µM, respectively. It exhibits anticancer activity, making it suitable f...		Others
T63259	PP2A Cancerous-IN-1
	PP2A Cancerous-IN-1 is a potent inhibitor of CIP2A (Cancerous inhibitor of PP2A) and p-Akt that exhibits potent anti-proliferative effects.
T9744	MP07-66		Phosphatase
	MP07-66 is a novel FTY720-analog devoid of immunosuppressive effects leads to the reactivation of PP2A, which in turn triggers apoptosis of CLL cells.		Phosphatase
TN1305	Ethoxysanguinarine	6-Ethoxydihydrosanguinarine	Apoptosis , AChR
	Ethoxysanguinarine (6-Ethoxydihydrosanguinarine) shows human blood acetylcholinesterase (HuAChE) and human plasma butyrylcholinesterase (HuBuChE) inhibitory activity, with IC50 values of 0.83 +/- 0.04 microM and 4.20 +/-...		Apoptosis , AChR
T35528	TD52		Apoptosis , Phosphatase , Akt
	TD52 is an orally active inhibitor of cancerous inhibitor of PP2A (CIP2A). TD52 is an Erlotinib derivative and indirectly reduced CIP2A by disturbing Elk1 binding to the CIP2A promoter.		Apoptosis , Phosphatase , Akt
T70131	TPP2a bromide
	TPP2a is a mitochondrial thioredoxin reductase (TrxR) inhibitor.
T4449	LB100	LB-100,LB 100	Phosphatase
	LB100 (LB-100) is a water soluble protein phosphatase 2A (PP2A) inhibitor.		Phosphatase
T60688	MKI-1	MASTL Kinase Inhibitor-1	Others
	MKI-1 (MASTL Kinase Inhibitor-1) is an inhibitor of MASTL (microtubule-associated serine/threonine kinase-like, IC50= 9.9 μM). MKI-1 exerts radiosensitizer and antitumor activities through PP2A activation in breast cance...		Others
T5182	AMZ30		Others
	AMZ30 is a selective inhibitor of PME-1 (IC50: 600 nM). It also reduces the demethylated form of PP2A in living cells.		Others
T2068	(Rac)-LB-100		Phosphatase
	LB-100, a novel Protein Phosphatase 2A (PP2A) inhibitor, sensitizes malignant meningioma cells to the therapeutic effects of radiation		Phosphatase
T3635	IQ 1	IQ1,IQ-1	Wnt/beta-catenin
	IQ 1 has multiple roles, such as maintaining the multifunctionality of mouse ESCs, decreasing Wnt-stimulated phosphorylation, blocking PP2A/Nkd interactions, and so on.		Wnt/beta-catenin
T5891	D-ERYTHRO-SPHINGOSINE	trans-4-Sphingenine,erythro-C18-Sphingosine,Erythrosphingosine	Phosphatase , Endogenous Metabolite , PKC
	D-erythro-Sphingosine (trans-4-Sphingenine) is a protein kinase C (PKC) inhibitor. D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator		Phosphatase , Endogenous Metabolite , PKC
T35528L	TD52 dihydrochloride	TD52 dihydrochloride(1798328-24-1 Free base),TD52 2HCl	Others
	TD52 dihydrochloride (TD52 2HCl), a derivative of Erlotinib, is a potent and orally active inhibitor of protein phosphatase 2A (CIP2A). It exhibits strong anti-cancer properties by regulating the CIP2A/PP2A/p-Akt signali...		Others
T12934	SMAP-2	DT-1154	Phosphatase
	SMAP-2 is an orally bioavailable activator of phosphatase 2A (PP2A) which binds to the PP2A Aα scaffold subunit to drive conformational changes in PP2A. It inhibits the growth of KRAS-mutant lung cancers .		Phosphatase
T26164	Rubratoxin A
	Rubratoxin A is a classical mycotoxin used as a PP2A-specific inhibitor.
T14859	Calyculin A	(-)-Calyculin A	Others
	Calyculin A is a potent and cell-permeable inhibitor of protein phosphatase 1 (PP1; IC50s: 2 nM). It also is a protein phosphatase 2A (PP2A) inhibitor (IC50s: 0.5-1 nM).		Others
T13095	Tautomycin		Others
	Tautomycin is a potent and specific protein phosphatases 1 and 2A inhibitor (Kiapp of 0.16 nM and 0.4 nM for PP1 and PP2A, respectively), and is an antifungal antibiotic isolated from the bacterium Streptomyces verticill...		Others
T35806	N-Stearoylsphingosine	C(18:0)/C(18:1),Cer(d18:1/18:0),C18 Ceramide (d18:1/18:0),C18 Ceramide	Phosphatase
	N-Stearoylsphingosine is an amide compound widely found in eukaryotic organisms that enhances protein phosphatase 2A (PP2A) activity by interfering with the binding of PP2A to PP2A inhibitor 2, leading to dephosphorylati...		Phosphatase
T78681	ITH12711		Phosphatase
	ITH12711, a PP2A ligand, can traverse the blood-brain barrier (BBB) and exerts neuroprotection by restoring PP2A-phosphatase activity [1].		Phosphatase
T10060	(1S,2S,3R)-DT-061		Others
	(1S,2S,3R)-DT-061 is an enantiomer of DT-061 which is an orally bioavailable activator of PP2A.		Others