Home Tools
Log in
Cart

Search Result

Search Results for " nadph-oxidase "

Targets

41

Compounds

5

Natural Products

10

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T4359 VAS2870 NADPH
VAS2870 is an inhibitor of NADPH oxidase (NOX).
T8107 GLX351322 NADPH-oxidase , NADPH
GLX351322 is NADPH Oxidase 4 Inhibitor with IC50 of 5 μM.
T8408 GKT136901 AK120765 NADPH-oxidase , NADPH
GKT136901 (AK120765) is an inhibitor of NOX1/4.It acts as Selective and Direct Scavenger of Peroxynitrite
T7042 1,5-Isoquinolinediol PARP
1, 5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50: 0.39 μM). The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1, 5-Isoquinolinediol...
T15433 GSK2795039 Apoptosis , Reactive Oxygen Species , ROS , NADPH
GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 decreases apoptosis. GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) (pIC50: 6 in different cell-free assays).
T6099 Setanaxib GKT137831 NADPH-oxidase , Ferroptosis , NADPH
Setanaxib (GKT137831) is a potent, specific dual NADPH oxidase (NOX1/4) inhibitor.
T22990 ML-090 Fluoflavine NADPH-oxidase , Others
ML-090 is NOX1-specific inhibitor(IC50 = 90 nM) which is >100 selectivity for NOX1 over NOX2, NOX3, NOX4 (all IC50s >10 μM).
T7191 Diphenyleneiodonium chloride DPI NOS , Reactive Oxygen Species , NADPH , TRP/TRPV Channel
Diphenyleneiodonium chloride (DPI)(DPI) is an irreversible inhibitor of iNOS and eNOS (IC50 values of 50 nM and 0.3 μM, respectively),and displays broad-spectrum bactericidal activity.
T10353 APX-115 free base Ewha-18278 free base NADPH-oxidase , NADPH
APX-115 free base (Ewha-18278 free base) (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4). APX-115 effectively prevents kid...
T38423 CL097 CL097 Reactive Oxygen Species , TLR
CL097 is an effective agonist of TLR7 and TLR8. CL097 induces pro-inflammatory cytokines in macrophages and NADPH oxidase priming, thereby increasing the fMLF-stimulated ROS production.
T83625 INOS-IN-14 3-bromo-1H-indazole-7-carbonitrile NOS
iNOS-IN-14 (3-bromo-1H-indazole-7-carbonitrile) is a potent nitric oxide synthase (NOS) inhibitor that inhibits the NADPH oxidase activity of nNOS.
T29097 VAS 3947 VA-S3947,VA S3947,VAS3947 Apoptosis , NADPH-oxidase
VAS 3947 is a specific inhibitor of NADPH oxidase (NOX).VAS 3947 has a potent anti-platelet effect, inducing apoptosis through UPR activation, mainly due to protein aggregation and misfolding, independent of anti-NOX act...
TP1886L1 NoxA1ds acetate(1435893-78-9 free base) NADPH-oxidase
NoxA1ds acetate is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 : 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human col...
T22096 L 012 sodium salt
L 012 sodium salt, a luminol analogue, is a widely used chemiluminescent (CL) probe for active oxygen and active nitrogen. L 012 sodium salt is widely used to detect the superoxides (O2•−) derived from NADPH oxidase (Nox...
T10354 APX-115 Ewha-18278 NADPH-oxidase
APX-115 (Ewha-18278) (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4). APX-115 effectively prevents kidney injury.
T15300 Fluorofenidone AKF-PD Others
Fluorofenidone (AKF-PD) attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway. Fluorofenidone is an an...
T13112 Tat-NR2B9c Tat-NR2Bct,NA-1 NO Synthase , iGluR
Tat-NR2B9c (NA-1) is a postsynaptic density-95 (PSD-95) inhibitor with neuroprotective and antiepileptic effects.Tat-NR2B9c inhibits PSD-95d2, PSD-95d1, and PSD-95, which prevents the activation of NMDA-induced NADPH oxi...
T0825 Ebselen SPI-1005,PZ-51,CCG-39161 Phosphatase , Virus Protease , Calcium Channel , COX , HIV Protease
Ebselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced b...
T12781 RV01 Others
RV01 is a novel quinoline-substituted analogue of resveratrol that inhibits DNA damage, reduces ethanol-induced acetaldehyde dehydrogenase (ALDH2) mRNA expression, and has hydroxyl radical scavenging activity. rV01 reduc...
T69630 Diphenyleneiodonium (free base)
Diphenyleneiodonium (free base) is an NADPH oxidase inhibitor.
T71513 GK-136901
GK-136901 is a first-in-class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitor.
T80243 Gp91 ds-tat
Gp91phox ds-tat, a biologically active peptide, functions as an inhibitor of NADPH oxidase assembly.
T11333 Fulvene-5 Others
Fulvene-5 is a chemical compound that exhibits antitumor activity. It functions as a potent inhibitor of NADPH oxidase 4 (NOX4) and possesses antioxidant properties. Additionally, Fulvene-5 acts as a reactive oxygen spec...
TP2083 Ac9-25
N-terminal peptide of Annexin I (AI/Lipocortin I) that inhibits leukocyte extravasation. Acts as a formyl peptide receptor 1 (FPR1) ligand and stimulates neutrophil NADPH oxidase activation.
T78592 Diapocynin Dehydrodiacetovanillone
Diapocynin (Dehydrodiacetovanillone), a dimer of Apocynin, acts as an orally administered inhibitor of NADPH oxidase. It exhibits anti-inflammatory, neuroprotective, and antioxidant properties [1].
T75813 Ac9-25 TFA
Ac9-25 TFA, an N-terminal peptide of Annexin I, functions as a formyl peptide receptor (FPR) agonist, activating neutrophil NADPH oxidase via FPR [1] [2].
TP1886 NoxA1ds
Potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 = 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. Atte...
T75949 NoxA1ds TFA
NoxA1ds TFA is a potent and selective inhibitor of NADPH oxidase 1 (NOX1), with an inhibition concentration (IC50) of 20 nM, demonstrating selectivity over NOX2, NOX4, NOX5, and xanthine oxidase. It effectively inhibits ...
T35393 Gp91ds-tat gp91ds-tat NADPH-oxidase
gp91ds-tat is a useful organic compound for research related to life sciences and the catalog number is T35393.
T60517 CL097 hydrochloride
CL097 hydrochloride is a potent TLR7 and TLR8 agonist. CL097 hydrochloride induces pro-inflammatory cytokines in macrophages and NADPH oxidase priming, thereby increasing the fMLF-stimulated ROS production [2].
TP1585 Sgp91 ds-tat Peptide 2, scrambled
This peptide is a scrambled sequence of NADPH oxidase assembly peptide inhibitor gp91 ds-tat. It is used as a control peptide. It is two amino acid residues shorter at the N-terminus compared to the scrambled gp91 ds-tat...
T73896 Glucose-6-phosphate dehydrogenase
Glucose-6-phosphate dehydrogenase, the crucial rate-limiting enzyme in the pentose phosphate pathway, plays a vital role in generating NADPH. This compound is indispensable for numerous critical cellular functions such a...
T38646 GKT136901 hydrochloride GKT136901 hydrochloride
GKT136901 hydrochloride is a powerful, selective, and orally active inhibitor of NADPH oxidase (NOX1/4). It exhibits K i values of 160 nM and 165 nM against NOX1 and NOX4, respectively. Additionally, GKT136901 hydrochlor...
T75815 WKYMVM-NH2 TFA
WKYMVM-NH2 TFA, a potent agonist for N-formyl peptide receptor (FPR1) and FPRL1/2, activates key leukocyte effector functions including chemotaxis, complement receptor-3 mobilization, and NADPH oxidase activation, as doc...
TP1948 PBP10 PBP 10
Selective formyl peptide receptor 2 (FPR2) antagonist; cell permeable. Selectively inhibits FPR2-mediated NADPH oxidase activity but has no effect on FPR1 signaling in neutrophils. Displays PIP2 binding activity in vitro...
T14021 20-HETE 20-hydroxy Arachidonic Acid Others
20-HETE (20-hydroxy Arachidonic Acid) is a CYP450 metabolite and a potent vasoconstrictor and it is an endogenous inhibitor of the large-conductance Ca2+-activated K+ channel in renal arterioles. 20-HETE increases NADPH ...
T62004 (Rac)-Nebivolol
(Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective antagonist of β1-adrenergic receptor (IC 50= 0.8 nM). Nebivolol shows Vasodilatory activity. In the early stages of ethanol-ind...
T63847 1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium
Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium (18:1 Lyso-PS) is a modified PS product obtained through NADPH oxidase activation and Lyso-PS signal transduction. Oleoyl-2-hydroxy-sn-glycero-3phospho-L-serine sodiu...
TP1891 MMK 1
Potent and selective human formyl peptide receptor FPR2 agonist (EC50 values are 1, 2 and > 10 000 nM at mFRP2, hFPR2 and hFPR1 respectively). Induces migration of human monocytes and neutrophils via a chemotactic mechan...
T71328 Theobromine-d6
Theobromine-d6 is intended for use as an internal standard for the quantification of theobromine by GC- or LC-MS. Theobromine is a methylxanthine alkaloid and derivative of caffeine that has been found in cocoa beans and...
T37583 XTT (sodium salt hydrate)
XTT is a cell-impermeable, negatively charged tetrazolium dye that produces a water-soluble formazan when reduced at the cell surface by cellular-derived NADH and an electron mediator.1,2It is frequently used in colorime...

Compounds

VAS2870
T4359
Synonym:
Target: NADPH
GLX351322
T8107
Synonym:
Target: NADPH-oxidase, NADPH
GKT136901
T8408
Synonym: AK120765
Target: NADPH-oxidase, NADPH
1,5-Isoquinolinediol
T7042
Synonym:
Target: PARP
GSK2795039
T15433
Synonym:
Target: Apoptosis, Reactive Oxygen Species, ROS, NADPH
Setanaxib
T6099
Synonym: GKT137831
Target: NADPH-oxidase, Ferroptosis, NADPH
ML-090
T22990
Synonym: Fluoflavine
Target: NADPH-oxidase, Others
Diphenyleneiodonium chloride
T7191
Synonym: DPI
Target: NOS, Reactive Oxygen Species, NADPH, TRP/TRPV Channel
APX-115 free base
T10353
Synonym: Ewha-18278 free base
Target: NADPH-oxidase, NADPH
CL097
T38423
Synonym: CL097
Target: Reactive Oxygen Species, TLR
iNOS-IN-14
T83625
Synonym: 3-bromo-1H-indazole-7-carbonitrile
Target: NOS
VAS 3947
T29097
Synonym: VA-S3947,VA S3947,VAS3947
Target: Apoptosis, NADPH-oxidase
NoxA1ds acetate(1435893-78-9 free base)
TP1886L1
Synonym:
Target: NADPH-oxidase
L 012 sodium salt
T22096
Synonym:
Target:
APX-115
T10354
Synonym: Ewha-18278
Target: NADPH-oxidase
Fluorofenidone
T15300
Synonym: AKF-PD
Target: Others
Tat-NR2B9c
T13112
Synonym: Tat-NR2Bct,NA-1
Target: NO Synthase, iGluR
Ebselen
T0825
Synonym: SPI-1005,PZ-51,CCG-39161
Target: Phosphatase, Virus Protease, Calcium Channel, COX, HIV Protease
RV01
T12781
Synonym:
Target: Others
Diphenyleneiodonium (free base)
T69630
Synonym:
Target:
GK-136901
T71513
Synonym:
Target:
gp91 ds-tat
T80243
Synonym:
Target:
Fulvene-5
T11333
Synonym:
Target: Others
Ac9-25
TP2083
Synonym:
Target:
Diapocynin
T78592
Synonym: Dehydrodiacetovanillone
Target:
Ac9-25 TFA
T75813
Synonym:
Target:
NoxA1ds
TP1886
Synonym:
Target:
NoxA1ds TFA
T75949
Synonym:
Target:
gp91ds-tat
T35393
Synonym: gp91ds-tat
Target: NADPH-oxidase
CL097 hydrochloride
T60517
Synonym:
Target:
sgp91 ds-tat Peptide 2, scrambled
TP1585
Synonym:
Target:
Glucose-6-phosphate dehydrogenase
T73896
Synonym:
Target:
GKT136901 hydrochloride
T38646
Synonym: GKT136901 hydrochloride
Target:
WKYMVM-NH2 TFA
T75815
Synonym:
Target:
PBP10
TP1948
Synonym: PBP 10
Target:
20-HETE
T14021
Synonym: 20-hydroxy Arachidonic Acid
Target: Others
(Rac)-Nebivolol
T62004
Synonym:
Target:
1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium
T63847
Synonym:
Target:
MMK 1
TP1891
Synonym:
Target:
Theobromine-d6
T71328
Synonym:
Target:
XTT (sodium salt hydrate)
T37583
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T6391 Apocynin Acetovanillone,Acetoguaiacone,NSC 2146 Apoptosis , NADPH , Autophagy
Apocynin (NSC 2146) is a specific NADPH-oxidase inhibitor (IC50: 10 μM).
TN2126 Quercetin-3-O-glucose-6''-acetate 6"-O-Acetylisoquercitrin NADPH-oxidase , ROS , NADPH
Quercetin-3-O-glucose-6''-acetate (6"-O-Acetylisoquercitrin) is an inhibitor of NADPH oxidase. Quercetin-3-O-glucose-6''-acetate has antioxidant activities.
T5S2343 Acetylshikonin Acetyl shikonin Others , P450 , AChE
1. Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC5 of over 2 microM, exhibits the antiangiogenic and antitumorigenic effects by suppressing proliferation and ang...
TN2039 Panaxydol cAMP , p38 MAPK , JNK
Panaxydol has anti-cancer activity, can inhibit the growth and apoptosis of cancer cells, the signaling mechanisms involve a [Ca(2+)](i) increase, JNK and p38 MAPK activation, cAMP, MAP kinase and ROS generation through ...
TN6515 Selaginellin
Selaginellin has a neuroprotective effect against L-glutamate-induced neurotoxicity through mechanisms related to anti-oxidation and anti-apoptosis via scavenging reactive oxygen species and up-regulating the expression ...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPJ-00848 NCF1 Protein, Human, Recombinant (His) Human E. coli
Neutrophil cytosol factor 1( NCF1) is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is characterized as a multicomponent enzyme which is activated to produce superoxide anion. NCF2, NCF1, and a mem...
TMPH-03751 CYBB Protein, Human, Recombinant (His) Human E. coli
Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membr...
TMPY-03660 P67phox Protein, Human, Recombinant Human Baculovirus-Insect Cells
NCF2 (Neutrophil Cytosolic Factor 2, also known as NCF-2 and p67phox) is a Protein Coding gene. 4 alternatively spliced human isoforms have been reported. This gene encodes neutrophil cytosolic factor 2, the 67-kilodalto...
TMPY-03619 P67phox Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
NCF2 (Neutrophil Cytosolic Factor 2, also known as NCF-2 and p67phox) is a Protein Coding gene. 4 alternatively spliced human isoforms have been reported. This gene encodes neutrophil cytosolic factor 2, the 67-kilodalto...
TMPY-04475 RFK Protein, Human, Recombinant (His) Human E. coli
Flavokinase is a member of the transferases family, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. Flavokinase is an essential enzyme that catalyzes ...
TMPH-01746 NOX4 Protein, Human, Recombinant (E. coli, His) Human E. coli
Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor...
TMPH-01745 NOX4 Protein, Human, Recombinant (Cell-Free, His) Human in vitro E. coli expression system
Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor...
TMPY-02439 Rac2 Protein, Human, Recombinant (His) Human E. coli
Ras-related C3 botulinum toxin substrate 2 (Rac2) is a small G-protein belonging to the Ras subfamily of the GTPase family. Rac2 acts as an "on / off" switch for signal transduction cascades and motilities. When GDP is a...
TMPH-00297 S100A9 Protein, Bovine, Recombinant (His & Myc & SUMO) Bovine E. coli
S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal act...
TMPY-01187 Rac1 Protein, Human, Recombinant (GST) Human Baculovirus-Insect Cells
RAC1 is a GTPase that belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal re...
TargetMol