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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T68766 | Dp2mT | ||
Dp2mT is an iron chelator which inhibits HIV-1 transcription. | |||
T4297 | Flibanserin | BIMT-17BS,Girosa,BIMT-17 | Dopamine Receptor , 5-HT Receptor |
Flibanserin (Girosa) is a serotonergic antidepressant used to treat hypoactive sexual desire disorder. Flibanserin has been associated with a low rate of minor serum aminotransferase elevations during treatment but has n... | |||
T7652 | AM211 | AM211 free acid | Prostaglandin Receptor |
AM211 (AM211 free acid) is a potent and orally bioavailable antagonist of prostaglandin D2 (PGD2) receptor type 2 (DP2) | |||
T2664 | Timapiprant | OC000459 | GPR , Prostaglandin Receptor |
Timapiprant (OC000459) is a potent and selective D prostanoid receptor 2 (DP2) antagonist (IC50: 13 nM). | |||
T10691 | CAY10595 | GPR | |
CAY10595 is an antagonist of the CRTh2 (DP2) receptor with a Ki of 10 nM. | |||
T6399 | AZD1981 | GPR , Prostaglandin Receptor | |
AZD1981 is an effective and specific CRTh2 (DP2) receptor antagonist (IC50: 4 nM), showing >1000-fold selectivity over more than 340 other enzymes and receptors, including DP1. AZD1981 has been used in trials studying th... | |||
T7359 | CAY10471 Racemate | TM30089 Racemate | GPR , Prostaglandin Receptor |
CAY10471 Racemate (TM30089 Racemate) is a potent, highly selective CRTH2/DP 2 receptor antagonist. CAY10471 Racemate binds to the human CRTH2/DP2, DP1, and TP receptors( Ki values of 0.6, 1200, and >10,000 nM,respectivel... | |||
T14565 | BI-671800 | AP-761,Cmpd A | GPR , Prostaglandin Receptor |
BI-671800 (AP-761) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2). With IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2... | |||
T41073 | Pexopiprant | ||
Pexopiprant, a potent oral antagonist of the prostaglandin D2 receptor 2 (DP2) with a K i value less than 100nM, is a valuable compound for asthma research. | |||
T17099 | Timapiprant sodium | OC000459 sodium | Others |
Timapiprant sodium inhibits mast cell activation of Th2 lymphocytes and eosinophils. Timapiprant sodium is a potent and selective D prostanoid receptor 2 antagonist. Timapiprant sodium potently displaces [3H] PGD2 from h... | |||
T10891 | CRTH2-IN-1 | Ramatroban analog | P450 |
CRTH2-IN-1 is a selective prostaglandin D2 receptor DP2 (CRTH2) antagonist, a Ramatroban analog, with an IC50 of 6 nM in the human DP2 binding assay. | |||
T71244 | AM-461 | ||
AM-461 is a DP2 receptor antagonist. | |||
T70989 | AM-461 sodium | ||
AM-461 sodium is the sodium salt of AM-461 --- a novel DP2 receptor antagonist | |||
T27799 | LAS191859 | LAS-191859,LAS 191859 | |
LAS191859 is a CRTH2/DP2 antagonist with IC50 values of 7.6, 9.58, 14 and 15.5nM for recombinant guinea pig, human, rat and mouse CRTH2/DP2 receptors, respectively. LAS191859 has a residence time half-life of 21h at CRTh... | |||
T38365 | CAY10597 | ||
The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. In humans, CRTH2/DP2 is expressed on Th2 cells, eosinophils, and... | |||
T37264 | 15(R)-15-methyl Prostaglandin D2 | 15(R)15methyl PGD2 | GPR |
15(R)-15-methyl Prostaglandin D2 (15(R)15methyl PGD2) is a synthetic analogue of PGD2 and a selective and potent CRTH2/DP2 receptor agonist that modulates eosinophil CD11b expression, actin polymerisation and chemotaxis. | |||
T82239 | HAP-1 | ||
HAP-1, a synovial-targeted transduction peptide, selectively mediates the internalization of protein complexes into synovial cells of human and rabbit origin. When fused with the antimicrobial peptide (KLAK)2, HAP-1 form... | |||
T36545 | Prostaglandin D2 methyl ester | Prostaglandin D2 methyl ester | |
Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is produced in large quantities by hematopoietic PGD synthase during allergic and asthmatic anaphylaxis. It causes vasodilation, flushing, hypoten... | |||
T71088 | AM-211 sodium | ||
AM-211 sodium is a novel and potent antagonist of the prostaglandin D2 receptor type 2. AM-211 is active in animal models of allergic inflammation. AM211 has high affinity for human, mouse, rat, and guinea pig DP2 and it... | |||
T14211 | AMG-009 | Others | |
AMG-009 is a prostaglandin D2 antagonist. For CRTH2 and DP receptors, the IC50s are 3 nM and 12 nM, respectively. |