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Search Results for " dp2 "

20

Compounds

Cat No. Product Name Synonyms Targets
T68766 Dp2mT
Dp2mT is an iron chelator which inhibits HIV-1 transcription.
T4297 Flibanserin BIMT-17BS,Girosa,BIMT-17 Dopamine Receptor , 5-HT Receptor
Flibanserin (Girosa) is a serotonergic antidepressant used to treat hypoactive sexual desire disorder. Flibanserin has been associated with a low rate of minor serum aminotransferase elevations during treatment but has n...
T7652 AM211 AM211 free acid Prostaglandin Receptor
AM211 (AM211 free acid) is a potent and orally bioavailable antagonist of prostaglandin D2 (PGD2) receptor type 2 (DP2)
T2664 Timapiprant OC000459 GPR , Prostaglandin Receptor
Timapiprant (OC000459) is a potent and selective D prostanoid receptor 2 (DP2) antagonist (IC50: 13 nM).
T10691 CAY10595 GPR
CAY10595 is an antagonist of the CRTh2 (DP2) receptor with a Ki of 10 nM.
T6399 AZD1981 GPR , Prostaglandin Receptor
AZD1981 is an effective and specific CRTh2 (DP2) receptor antagonist (IC50: 4 nM), showing >1000-fold selectivity over more than 340 other enzymes and receptors, including DP1. AZD1981 has been used in trials studying th...
T7359 CAY10471 Racemate TM30089 Racemate GPR , Prostaglandin Receptor
CAY10471 Racemate (TM30089 Racemate) is a potent, highly selective CRTH2/DP 2 receptor antagonist. CAY10471 Racemate binds to the human CRTH2/DP2, DP1, and TP receptors( Ki values of 0.6, 1200, and >10,000 nM,respectivel...
T14565 BI-671800 AP-761,Cmpd A GPR , Prostaglandin Receptor
BI-671800 (AP-761) is a highly specific and potent antagonist of chemoattractant receptor-homologous molecule on Th2 cells (DP2/CRTH2). With IC50 values of 4.5 nM and 3.7 nM for PGD2 binding to CRTH2 in hCRTH2 and mCRTH2...
T41073 Pexopiprant
Pexopiprant, a potent oral antagonist of the prostaglandin D2 receptor 2 (DP2) with a K i value less than 100nM, is a valuable compound for asthma research.
T17099 Timapiprant sodium OC000459 sodium Others
Timapiprant sodium inhibits mast cell activation of Th2 lymphocytes and eosinophils. Timapiprant sodium is a potent and selective D prostanoid receptor 2 antagonist. Timapiprant sodium potently displaces [3H] PGD2 from h...
T10891 CRTH2-IN-1 Ramatroban analog P450
CRTH2-IN-1 is a selective prostaglandin D2 receptor DP2 (CRTH2) antagonist, a Ramatroban analog, with an IC50 of 6 nM in the human DP2 binding assay.
T71244 AM-461
AM-461 is a DP2 receptor antagonist.
T70989 AM-461 sodium
AM-461 sodium is the sodium salt of AM-461 --- a novel DP2 receptor antagonist
T27799 LAS191859 LAS-191859,LAS 191859
LAS191859 is a CRTH2/DP2 antagonist with IC50 values of 7.6, 9.58, 14 and 15.5nM for recombinant guinea pig, human, rat and mouse CRTH2/DP2 receptors, respectively. LAS191859 has a residence time half-life of 21h at CRTh...
T38365 CAY10597
The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. In humans, CRTH2/DP2 is expressed on Th2 cells, eosinophils, and...
T37264 15(R)-15-methyl Prostaglandin D2 15(R)15methyl PGD2 GPR
15(R)-15-methyl Prostaglandin D2 (15(R)15methyl PGD2) is a synthetic analogue of PGD2 and a selective and potent CRTH2/DP2 receptor agonist that modulates eosinophil CD11b expression, actin polymerisation and chemotaxis.
T82239 HAP-1
HAP-1, a synovial-targeted transduction peptide, selectively mediates the internalization of protein complexes into synovial cells of human and rabbit origin. When fused with the antimicrobial peptide (KLAK)2, HAP-1 form...
T36545 Prostaglandin D2 methyl ester Prostaglandin D2 methyl ester
Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is produced in large quantities by hematopoietic PGD synthase during allergic and asthmatic anaphylaxis. It causes vasodilation, flushing, hypoten...
T71088 AM-211 sodium
AM-211 sodium is a novel and potent antagonist of the prostaglandin D2 receptor type 2. AM-211 is active in animal models of allergic inflammation. AM211 has high affinity for human, mouse, rat, and guinea pig DP2 and it...
T14211 AMG-009 Others
AMG-009 is a prostaglandin D2 antagonist. For CRTH2 and DP receptors, the IC50s are 3 nM and 12 nM, respectively.
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