Anatabine

Anatabine dicitrate, a tobacco alkaloid that can cross the blood-brain barrier, is a potent α4β2 nAChR agonist and inhibits NF-κB activation, thereby reducing amyloid-β (Aβ) production by preventing β-cleavage of the amyloid precursor protein.

Anatabine is a minor tobacco alkaloid with a chemical structural similarity to nicotine. Anatabine is produced in plants of the Solanacea family including tobacco, green tomatoes, peppers, and eggplants. Anatabine is an Aβ inhibitor. (R,S)-Anatabine (tart

(R)-(+)-Anatabine, the less active R-enantiomer of Anatabine, is a potent agonist of α4β2 nAChR.

(R,S)-Anatabine is a minor tobacco alkaloid found in the Solanaceae family of plants, and serves as a specific marker for detecting tobacco use.

(S)-(-)-Anatabine ((-)-Anatabine), an alkaloid present in tobacco, is an NRF2 activator that attenuates ovalbumin-induced asthma through oxidative stress and inflammation mitigation as well as up-regulation of Nrf2/HO-1 signaling in rats, and may be used in the study of autoimmune thyroiditis.

(S)-N-Nitrosoanatabine ((S)-N-NAT) is a potent carcinogen and serves as a biomarker for exposure to cigarette smoke. It is found in various tobacco products as well as in oral inhalants.

N-Nitrosoanatabine-d3 (N-NAT-d3) is a deuterium-labeled form of N-Nitrosoanatabine. N-Nitrosoanatabine (N-NAT; N'-Nitrosoanatabine) is a tobacco-specific nitrosamine (TSNA), found in tobacco, tobacco products, and e-cigarettes. The (S) enantiomer constitutes approximately 80% of N-NAT in commercial cigarettes and smokeless tobacco used for research. Unlike other TSNAs, N-NAT does not exhibit carcinogenicity in rats when administered at doses of 1, 3, and 9 mmol/kg.

N-Nitrosoanatabine (N-NAT; N'-Nitrosoanatabine) is a tobacco-specific nitrosamine (TSNA) found in tobacco, tobacco products, and e-cigarettes. The (S) enantiomer constitutes approximately 80% of N-NAT in commercial and research-use cigarettes and smokeless tobacco. Unlike other TSNAs, N-NAT does not exhibit carcinogenicity in rats when administered at doses of 1, 3, and 9 mmol/kg.