5α-dihydrotestosterone

Exemestane (EXE) is an Aromatase Inhibitor. The mechanism of action of exemestane is as an Aromatase Inhibitor.

5α-Dihydrotestosterone-D4 is a deuterated compound of 5α-Dihydrotestosterone. 5α-Dihydrotestosterone (T84319) has a CAS number of 521-18-6. Dihydrotestosterone is a potent androgenic metabolite of testosterone. It is an agonist of the androgen receptor.

11β-Hydroxy-5α-Dihydrotestosterone-D4 (Standard) is a reference standard of 11β-Hydroxy-5α-Dihydrotestosterone-[D4] intended for quantitative analysis, quality control, and related biochemical research applications.

SRD5A1-IN-1 is an inhibitor of steroid 5α-reductase type 1 (SRD5A1, IC50 = 1.44 µM). SRD5A1-IN-1 lowers the production of dihydrotestosterone and shows a significant decrease in the SRD5A1 protein expression.

4-Androsten-3-one-5-ene-17-carboxylic acid is a derivative of progesterone and functions as a 5α-reductase inhibitor. It prevents the transformation of testosterone into dihydrotestosterone in homogenates of the rat ventral prostate.

SRD5A1-IN-2 is a steroid 5α-reductase type 1 (SRD5A1) inhibitor with an IC50 of 8.5 μM. It decreases the expression of the SRD5A1 protein in HaCaT cells and reduces the production of dihydrotestosterone (DHT) in these cells. This compound may be utilized in the study of androgen-related disorders such as androgenetic alopecia (AGA).

1. Isocurcumenol inhibits 5α-reductase which converts testosterone to dihydrotestosterone (DHT).

N-Nitrosodicyclohexylamine (NDCHA), an N-nitrosocompound, exhibits anti-androgenic activity by competitively binding to the androgen receptor (AR) in opposition to 5α-dihydrotestosterone and reducing AR protein levels [1].

5α-Reductase is the enzyme responsible for converting testosterone into 5-α dihydrotestosterone (DHT), a potent androgen involved in male sexual differentiation. The 5α-reductase family comprises three subfamilies and five isozyme members: 5αR1, 5αR2, 5αR3, GPSN2, and GPSN2L.