5α-dihydrotestosterone

5α-Dihydrotestosterone-d4 is a deuterated compound of 5α-Dihydrotestosterone. 5α-Dihydrotestosterone has a CAS number of 521-18-6. Dihydrotestosterone is a potent androgenic metabolite of testosterone. It is an agonist of the androgen receptor.

11β-Hydroxy-5α-Dihydrotestosterone-[D4] (Standard) is a reference standard of 11β-Hydroxy-5α-Dihydrotestosterone-[D4] intended for quantitative analysis, quality control, and related biochemical research applications.

Exemestane (EXE) is an Aromatase Inhibitor. The mechanism of action of exemestane is as an Aromatase Inhibitor.

SRD5A1-IN-1 is an inhibitor of steroid 5α-reductase type 1 (SRD5A1, IC50 = 1.44 µM). SRD5A1-IN-1 lowers the production of dihydrotestosterone and shows a significant decrease in the SRD5A1 protein expression.

4-Androsten-3-one-5-ene-17-carboxylic acid is a derivative of progesterone and functions as a 5α-reductase inhibitor. It prevents the transformation of testosterone into dihydrotestosterone in homogenates of the rat ventral prostate.

1. Isocurcumenol inhibits 5α-reductase which converts testosterone to dihydrotestosterone (DHT).

N-Nitrosodicyclohexylamine (NDCHA), an N-nitrosocompound, exhibits anti-androgenic activity by competitively binding to the androgen receptor (AR) in opposition to 5α-dihydrotestosterone and reducing AR protein levels [1].

5α-Reductase is the enzyme responsible for converting testosterone into 5-α dihydrotestosterone (DHT), a potent androgen involved in male sexual differentiation. The 5α-reductase family comprises three subfamilies and five isozyme members: 5αR1, 5αR2, 5αR3, GPSN2, and GPSN2L.