3ap

3-AP (Triapine) is a novel inhibitor of the M2 subunit of ribonucleotide reductase (RR).

3-AP-Me is the dimethyl derivative of the ribonucleotide reductase inhibitor 3-AP (SML0568). It activates the endoplasmic reticulum (ER) stress pathway by promoting eIF2α phosphorylation and upregulating gene expression of transcription factors ATF4 and ATF6, thereby inducing apoptosis. Additionally, 3-AP-Me activates cellular stress kinases c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase, leading to the upregulation of spliced mRNA variant XBP1. It is applicable in cancer research.

(Ala13)-Apelin-13 acetate, an APJ antagonist, modulates CRF-induced enhanced colonic motility, visceral sensation, and gut barrier.

3-Aminopropylphosphinic acid (3-APPA), a phosphonic analog of gamma-aminobutyric acid (GABA), acts as a potent and selective agonist of the GABA B receptor.

(R)-tert-Butyl (4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate is a useful organic compound for research related to life sciences and the catalog number is T65597.

(2Z)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-yl]-1-(2,4,5-trifluorophenyl)but-2-en-2-amine is a useful organic compound for research related to life sciences. The catalog number is T66986 and the CAS number is 767340-03-4.

1-(3-(Trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butane-1,3-dione is a useful organic compound for research related to life sciences. The catalog number is T67692 and the CAS number is 764667-65-4.

Metitepine is a serotonin receptor antagonist in the CNS used as an antipsychotic.

3-Acetylpyridine adenine dinucleotide functions as an alternative reductant in glutamate-synthase-catalyzed glutamate synthesis. 3-Acetylpyridine adenine dinucleotide demonstrates kinetic parameters in the AcPdADH-dependent reaction wherein Kcat and Km values for other substrates are reduced approximately fourfold relative to the NADH-dependent reaction. 3-Acetylpyridine adenine dinucleotide shows a Km of ~3 µM and acts as a competitive inhibitor of NADH in NADH-dependent glutamate synthesis with a Ki of 1 µM. 3-Acetylpyridine adenine dinucleotide provides meaningful mechanistic insights into redox cofactor selectivity in enzymatic glutamate biosynthesis.

Rhamnocitrin 3-apiosyl-(1→2)-glucoside is a natural product for research related to life sciences. The catalog number is TN6650 and the CAS number is 148031-68-9.

A3-APO is an antimicrobial peptide that exhibits significant antibacterial activity through a dual mechanism of action (membrane lysis and inhibition of intracellular targets). It can neutralize bacterial toxins and enhance the expression of anti-inflammatory cytokines (such as IL-4 and IL-10) without leading to resistance. A3-APO also accelerates wound healing in burn-infected mouse models of Acinetobacter baumannii and Staphylococcus aureus.