2-ketoglutaric acid

2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM). 2-Ketoglutaric acid is an intermediate of the Krebs cycle and can produce either ATP or GTP. 2-Ketoglutaric acid also acts as a major carbon backbone for the nitrogen assimilation reaction.

2-Ketoglutaric acid potassium (Alpha-Ketoglutaric acid potassium) is an intermediate in the Krebs cycle where ATP or GTP is produced. It also serves as the primary carbon backbone in nitrogen assimilation reactions. Additionally, 2-Ketoglutaric acid potassium acts as a reversible inhibitor of tyrosinase with an IC50 value of 15 mM.

2-Ketoglutaric acid Sodium (AKG) is a key molecule in the TCA cycle. It can be produced from glutamate by oxidative deamination via glutamate dehydrogenase and as a product of pyridoxal phosphate-dependent transamination reactions (mediated by branched-chain amino acid transaminases) in which glutamate is a common amino donor.

2-Ketoglutaric acid (Standard) is a reference standard for research and analysis in studies involving 2-Ketoglutaric acid. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM). 2-Ketoglutaric acid is an intermediate of the Krebs cycle and can produce either ATP or GTP. 2-Ketoglutaric acid also acts as a major carbon backbone for the nitrogen assimilation reaction.

D-α-Hydroxyglutaric acid-d5 disodium (Disodium (R)-2-hydroxyglutarate-d5) is the deuterated version of D-α-Hydroxyglutaric acid disodium. This compound is a major metabolite that accumulates in the neurometabolic disorder D-2-hydroxyglutaric aciduria. As a weak competitive antagonist of α-ketoglutaric acid (α-KG), D-α-Hydroxyglutaric acid disodium inhibits various α-KG-dependent dioxygenases with a Ki of 10.87 mM. It also promotes the production of reactive oxygen species (ROS), binds to and inhibits ATP synthase, and suppresses mTOR signaling.