18β glycyrrhetinic acid

18β-Glycyrrhetinic acid (Enoxolone) is the major bioactive component of Glycyrrhizae Radix and possesses anti-ulcerative, anti-inflammatory and antiproliferative properties.

GA-O-02, an 18β-Glycyrrhetinic acid (GA) derivative, functions as a powerful antimicrobial and anti-inflammatory agent. This compound inhibits NO, pro-inflammatory cytokines, and chemokines to exert its anti-inflammatory effects. Additionally, GA-O-02 demonstrates significant antimicrobial activity against Gram-positive bacteria.

GA-O-06, an 18β-Glycyrrhetinic acid derivative, serves as a potent antimicrobial and anti-inflammatory agent. It achieves its anti-inflammatory effects by inhibiting NO, pro-inflammatory cytokines, and chemokines, while demonstrating significant antimicrobial activity against Gram-positive bacteria.

18β-Glycyrrhetyl-3-O-sulfate (Glycyrrhetic acid 3-O-(hydrogen sulfate)), a major metabolite of Glycyrrhetinic acid (GA), is a potent inhibitor of type 2 11β-hydroxysteroid dehydrogenase (11β-HSD2) with an IC50 value of 0.10 µM in rat kidney microsome assays. This compound is a substrate for organic anion transporters (OAT) 1 and OAT3, exhibits anti-inflammatory properties, and holds potential for research into pseudohyperaldosteronism [1] [2].

18β-Glycyrrhetinic acid (Standard) is the certified analytical reference standard of 18β-Glycyrrhetinic acid intended for quantitative and analytical research, representing the principal bioactive metabolite of Glycyrrhiza uralensis and exhibiting anti-ulcerative, anti-inflammatory, and antiproliferative properties relevant to pharmacological and natural product studies.